(+/-)-5-fluoro-1--2,4(1H,3H)-pyrimidinedione

Base Information

Chemical Name:(+/-)-5-fluoro-1--2,4(1H,3H)-pyrimidinedione
CAS No.:144100-67-4
Molecular Formula:C₂₉H₂₅FN₂O₃
Molecular Weight:468.528
Hs Code.:

(+/-)-5-fluoro-1-<cis-4-(triphenylmethoxymethyl)-2-cyclopenten-1-yl>-2,4(1H,3H)-pyrimidinedione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-5-fluoro-1--2,4(1H,3H)-pyrimidinedione

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Technology Process of (+/-)-5-fluoro-1--2,4(1H,3H)-pyrimidinedione

There total 8 articles about (+/-)-5-fluoro-1--2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 144100-62-9
(+/-)-5-fluoro-1-<(1β,3β,4β)-3-(methylsulfonyloxy)-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

: 144100-66-3
(+/-)-5-fluoro-1-<3-(triphenylmethoxymethyl)-3-cyclo-penten-1-yl>-2,4(1H,3H)-pyrimidinedione

: 144100-63-0
(+/-)-5-fluoro-1-<(1β,3α,4β)-3-chloro-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

: 144100-67-4
(+/-)-5-fluoro-1--2,4(1H,3H)-pyrimidinedione

Guidance literature:: With tetrabutyl-ammonium chloride; In N,N-dimethyl-formamide; Yields of byproduct given; 1) 85 deg C, 1 h, 2) r. t., overnight;
DOI:10.1139/v92-152

Reference yield: 42.0%

: 144100-62-9
(+/-)-5-fluoro-1-<(1β,3β,4β)-3-(methylsulfonyloxy)-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

: 144100-66-3
(+/-)-5-fluoro-1-<3-(triphenylmethoxymethyl)-3-cyclo-penten-1-yl>-2,4(1H,3H)-pyrimidinedione

: 144100-64-1
(+/-)-5-fluoro-1-<(1β,3α,4β)-3-bromo-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

: 144100-67-4
(+/-)-5-fluoro-1--2,4(1H,3H)-pyrimidinedione

Guidance literature:: With tetrabutylammomium bromide; In N,N-dimethyl-formamide; 1) 85 deg C, 1 h, 2) r. t., overnight;
DOI:10.1139/v92-152

Reference yield:

: 76-83-5
trityl chloride

: 144100-67-4
(+/-)-5-fluoro-1--2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / pyridine / 1 h / 100 °C

2: 83 percent / 16 h / Ambient temperature

3: n-Bu₄NCl / dimethylformamide / 1) 85 deg C, 1 h, 2) r. t., overnight

With pyridine; tetrabutyl-ammonium chloride; In N,N-dimethyl-formamide;
DOI:10.1139/v92-152