3(2H)-Benzofuranone, 4,6-dimethoxy-2-(4-methoxyphenyl)-

Base Information

Chemical Name:3(2H)-Benzofuranone, 4,6-dimethoxy-2-(4-methoxyphenyl)-
CAS No.:117828-33-8
Molecular Formula:C17H16O5
Molecular Weight:300.311
Hs Code.:
DSSTox Substance ID:DTXSID90462431
Nikkaji Number:J1.615.733C
Mol file:117828-33-8.mol

Synonyms:117828-33-8;4,6-Dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one;3(2H)-Benzofuranone, 4,6-dimethoxy-2-(4-methoxyphenyl)-;SCHEMBL6324673;DTXSID90462431

Suppliers and Price of 3(2H)-Benzofuranone, 4,6-dimethoxy-2-(4-methoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3(2H)-Benzofuranone, 4,6-dimethoxy-2-(4-methoxyphenyl)-

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:300.09977361
Heavy Atom Count:22
Complexity:391

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2C(=O)C3=C(O2)C=C(C=C3OC)OC

Technology Process of 3(2H)-Benzofuranone, 4,6-dimethoxy-2-(4-methoxyphenyl)-

There total 8 articles about 3(2H)-Benzofuranone, 4,6-dimethoxy-2-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 4225-35-8
4,6-dimethoxycoumaranone

: 117828-33-8
4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one

Guidance literature:: With sodium t-butanolate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; palladium diacetate; In toluene; at 60 - 80 ℃;
DOI:10.1002/ejoc.200400891

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 4225-35-8
4,6-dimethoxycoumaranone

: 4,6-dimethoxy-3-(4-methoxy-phenoxy)-benzofuran

: 117828-33-8
4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one

Guidance literature:: With potassium tert-butylate; 4-methoxy-phenol; palladacycle catalyst; In toluene; at 110 ℃;
DOI:10.1016/j.tetlet.2005.09.062

Reference yield:

: 33646-40-1
4-methoxymandelonitrile

: 117828-33-8
4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1) HCl(g), 2) 0.1 M aq. HCl / 1) 0 deg C, 1 h, 2) reflux, 3 h

2: 1) K₂CO₃, 2) 5percent aq. HCl / 1) (CH₃)2CO, reflux, 30 min, 2) MeOH, reflux, 3 h

With hydrogenchloride; potassium carbonate;