3',5'-dideoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-5'-thiothymidine

Base Information

Chemical Name:3',5'-dideoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-5'-thiothymidine
CAS No.:144944-90-1
Molecular Formula:C₁₉H₂₄N₂O₅S
Molecular Weight:392.476
Hs Code.:

Synonyms:

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Chemical Property of 3',5'-dideoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-5'-thiothymidine

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Technology Process of 3',5'-dideoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-5'-thiothymidine

There total 14 articles about 3',5'-dideoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-5'-thiothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 144944-92-3
5'-S-acetyl-3',5'-dideoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-5'-thiothymidine

: 144944-90-1
3',5'-dideoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-5'-thiothymidine

Guidance literature:: With ammonia; for 20h;

Reference yield:

: 58399-76-1
3-Deoxy-3-C-(2'-hydroxyethyl)-1,2-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranose

: 144944-90-1
3',5'-dideoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-5'-thiothymidine

Guidance literature:: Multi-step reaction with 10 steps

1: 91 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 0.33 h / Heating

2: 69 percent / 2.) camphorsulfonic acid / acetic acid / 70 °C / 1.) 15 min, 2.) 12 min

3: 91 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 6 h / Heating

4: 100 percent / methanolic ammonia / 10 h / Ambient temperature

5: 86 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

6: 87 percent / pyridine / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) refrigerator, 20 h

7: 93 percent / tri-n-butyltin hydride, AIBN / toluene / 4 h / 75 °C

8: tetra-n-butylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature

9: 87 percent / diisopropyl azodicarboxylate, PPh₃ / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) r.t., 40 min

10: 98 percent / methanolic ammonia / 20 h

With pyridine; 1H-imidazole; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; ammonia; tri-n-butyl-tin hydride; triphenylphosphine; diethylazodicarboxylate; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: 150-76-5
4-methoxy-phenol

: 144944-90-1
3',5'-dideoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-5'-thiothymidine

Guidance literature:: Multi-step reaction with 10 steps

1: 91 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 0.33 h / Heating

2: 69 percent / 2.) camphorsulfonic acid / acetic acid / 70 °C / 1.) 15 min, 2.) 12 min

3: 91 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 6 h / Heating

4: 100 percent / methanolic ammonia / 10 h / Ambient temperature

5: 86 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

6: 87 percent / pyridine / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) refrigerator, 20 h

7: 93 percent / tri-n-butyltin hydride, AIBN / toluene / 4 h / 75 °C

8: tetra-n-butylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature

9: 87 percent / diisopropyl azodicarboxylate, PPh₃ / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) r.t., 40 min

10: 98 percent / methanolic ammonia / 20 h

With pyridine; 1H-imidazole; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; ammonia; tri-n-butyl-tin hydride; triphenylphosphine; diethylazodicarboxylate; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;