N-<1-Acetyl-7-(benzyloxy)-3-methylindol-5-yl>acetohydroxamsaeure

Base Information

Chemical Name:N-<1-Acetyl-7-(benzyloxy)-3-methylindol-5-yl>acetohydroxamsaeure
CAS No.:127040-11-3
Molecular Formula:C₂₀H₂₀N₂O₄
Molecular Weight:352.39
Hs Code.:

Synonyms:

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Chemical Property of N-<1-Acetyl-7-(benzyloxy)-3-methylindol-5-yl>acetohydroxamsaeure

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Technology Process of N-<1-Acetyl-7-(benzyloxy)-3-methylindol-5-yl>acetohydroxamsaeure

There total 9 articles about N-<1-Acetyl-7-(benzyloxy)-3-methylindol-5-yl>acetohydroxamsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25945-96-4
2-benzyloxy-4-nitro-phenylamine

: 127040-11-3
N-<1-Acetyl-7-(benzyloxy)-3-methylindol-5-yl>acetohydroxamsaeure

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / N-bromosuccinimide / acetonitrile / 0.17 h / 55 °C

2: 87 percent / 4-(dimethylamino)pyridine / 48 h / 100 °C

3: 98 percent / NaOH / methanol / 2 h / Ambient temperature

4: 60 percent / Na₂CO₃ / dimethylformamide / 20 h / Heating

5: 74 percent / Bu₃N, Pd(OAc)2P(Tol₃)2 / toluene / 48 h / Heating

6: hydrogen, conc. NH₄OH, DMSO / 5 percent Pt/C / tetrahydrofuran / 1 h / 15 °C

7: NaHCO₃ / tetrahydrofuran; H₂O / 1 h / 0 °C

With dmap; ammonium hydroxide; sodium hydroxide; N-Bromosuccinimide; tributyl-amine; Pd(OAc)2P(Tol₃)2; hydrogen; sodium hydrogencarbonate; sodium carbonate; dimethyl sulfoxide; platinum on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/hlca.19890720717

Reference yield:

: 127028-17-5
2-(benzyloxy)-6-bromo-4-nitro-aniline

: 127040-11-3
N-<1-Acetyl-7-(benzyloxy)-3-methylindol-5-yl>acetohydroxamsaeure

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / 4-(dimethylamino)pyridine / 48 h / 100 °C

2: 98 percent / NaOH / methanol / 2 h / Ambient temperature

3: 60 percent / Na₂CO₃ / dimethylformamide / 20 h / Heating

4: 74 percent / Bu₃N, Pd(OAc)2P(Tol₃)2 / toluene / 48 h / Heating

5: hydrogen, conc. NH₄OH, DMSO / 5 percent Pt/C / tetrahydrofuran / 1 h / 15 °C

6: NaHCO₃ / tetrahydrofuran; H₂O / 1 h / 0 °C

With dmap; ammonium hydroxide; sodium hydroxide; tributyl-amine; Pd(OAc)2P(Tol₃)2; hydrogen; sodium hydrogencarbonate; sodium carbonate; dimethyl sulfoxide; platinum on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.19890720717

Reference yield:

: 100-44-7
benzyl chloride

: 127040-11-3
N-<1-Acetyl-7-(benzyloxy)-3-methylindol-5-yl>acetohydroxamsaeure

Guidance literature:: Multi-step reaction with 8 steps

1: 69 percent / K₂CO₃, KI / dimethylformamide / 4 h / 80 °C

2: 97 percent / N-bromosuccinimide / acetonitrile / 0.17 h / 55 °C

3: 87 percent / 4-(dimethylamino)pyridine / 48 h / 100 °C

4: 98 percent / NaOH / methanol / 2 h / Ambient temperature

5: 60 percent / Na₂CO₃ / dimethylformamide / 20 h / Heating

6: 74 percent / Bu₃N, Pd(OAc)2P(Tol₃)2 / toluene / 48 h / Heating

7: hydrogen, conc. NH₄OH, DMSO / 5 percent Pt/C / tetrahydrofuran / 1 h / 15 °C

8: NaHCO₃ / tetrahydrofuran; H₂O / 1 h / 0 °C

With dmap; ammonium hydroxide; sodium hydroxide; N-Bromosuccinimide; tributyl-amine; Pd(OAc)2P(Tol₃)2; hydrogen; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; dimethyl sulfoxide; potassium iodide; platinum on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/hlca.19890720717