Technology Process of N-isobutyl-6-{3-[4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenylcarbamoyl]-naphthalen-2-yl}-isophthalamic acid methyl ester
There total 6 articles about N-isobutyl-6-{3-[4-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenylcarbamoyl]-naphthalen-2-yl}-isophthalamic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 71 percent / PCl3; 4-dimethylaminopyridine (DMAP) / xylene / 1.5 h / 150 °C
2: 55 percent / Pd2(dba)3; Ph3As; CuI / dimethylformamide / 6 h / 60 °C
3: NH2OH*HCl / methanol / 12 h / 20 °C
4: trifluoroacetic acid / 4 h
With
dmap; copper(l) iodide; tris(dibenzylideneacetone)dipalladium (0); triphenyl-arsane; hydroxylamine hydrochloride; phosphorus trichloride;
In
methanol; N,N-dimethyl-formamide; trifluoroacetic acid; xylene;
1: Condensation / 2: Stille coupling reaction / 3: Addition / 4: Cyclization;
DOI:10.1016/S0040-4039(00)01016-9
- Guidance literature:
-
Multi-step reaction with 5 steps
1: KI; H2SO4 / H2O / 100 °C
2: 71 percent / PCl3; 4-dimethylaminopyridine (DMAP) / xylene / 1.5 h / 150 °C
3: 55 percent / Pd2(dba)3; Ph3As; CuI / dimethylformamide / 6 h / 60 °C
4: NH2OH*HCl / methanol / 12 h / 20 °C
5: trifluoroacetic acid / 4 h
With
dmap; copper(l) iodide; tris(dibenzylideneacetone)dipalladium (0); triphenyl-arsane; sulfuric acid; hydroxylamine hydrochloride; potassium iodide; phosphorus trichloride;
In
methanol; water; N,N-dimethyl-formamide; trifluoroacetic acid; xylene;
1: Iodination / 2: Condensation / 3: Stille coupling reaction / 4: Addition / 5: Cyclization;
DOI:10.1016/S0040-4039(00)01016-9
- Guidance literature:
-
Multi-step reaction with 6 steps
1: H2SO4; NaNO2 / H2O / 100 - 110 °C
2: KI; H2SO4 / H2O / 100 °C
3: 71 percent / PCl3; 4-dimethylaminopyridine (DMAP) / xylene / 1.5 h / 150 °C
4: 55 percent / Pd2(dba)3; Ph3As; CuI / dimethylformamide / 6 h / 60 °C
5: NH2OH*HCl / methanol / 12 h / 20 °C
6: trifluoroacetic acid / 4 h
With
dmap; copper(l) iodide; tris(dibenzylideneacetone)dipalladium (0); triphenyl-arsane; sulfuric acid; hydroxylamine hydrochloride; potassium iodide; sodium nitrite; phosphorus trichloride;
In
methanol; water; N,N-dimethyl-formamide; trifluoroacetic acid; xylene;
1: Diazotization / 2: Iodination / 3: Condensation / 4: Stille coupling reaction / 5: Addition / 6: Cyclization;
DOI:10.1016/S0040-4039(00)01016-9
