C₂₀H₂₉BrN₂O₄

Base Information

• Chemical Name: C₂₀H₂₉BrN₂O₄
• CAS No.: 1357394-18-3
• Molecular Formula: C₂₀H₂₉BrN₂O₄
• Molecular Weight: 441.365
• Mol file: 1357394-18-3.mol

Synonyms:

Chemical Property of C₂₀H₂₉BrN₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₉BrN₂O₄

There total 2 articles about C₂₀H₂₉BrN₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

tert-butoxycarbonyl-2-(tert-butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate (119838-44-7) + ortho-bromobenzaldehyde (6630-33-7) → C20H29BrN2O4 (1357394-18-3) + C20H29BrN2O4 (1357394-16-1) + C20H29BrN2O4 (1357394-15-0)

Guidance literature:

tert-butoxycarbonyl-2-(tert-butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

ortho-bromobenzaldehyde; In tetrahydrofuran; hexane; at -100 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1055/s-0031-1289577

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (+/-)-2-(tert-butyl)-3-methylimidazolidin-4-one (101055-55-4) → C20H29BrN2O4 (1357394-18-3) + C20H29BrN2O4 (1357394-16-1) + C20H29BrN2O4 (1357394-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1.2: Daicel Chiralpak IC / Resolution of racemate

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: -100 °C / Inert atmosphere

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane;

DOI:10.1055/s-0031-1289577

Reference yield:

C20H29BrN2O4 (1357394-18-3) → C14H18BrNO5 (1357394-20-7)

Guidance literature:

C₂₀H₂₉BrN₂O₄; With hydrogenchloride; In water; for 12h; Reflux;

With dmap; di-tert-butyl dicarbonate; sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 12h;

DOI:10.1055/s-0031-1289577

upstream raw materials:

di-tert-butyl dicarbonate

(+/-)-2-(tert-butyl)-3-methylimidazolidin-4-one

tert-butoxycarbonyl-2-(tert-butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate

ortho-bromobenzaldehyde

Downstream raw materials:

C₁₅H₂₀BrNO₅

C₁₇H₂₂BrNO₅

C₁₄H₁₈BrNO₅