Technology Process of (RS)-2-amino-3-(2-(2-carboxyethyl)-5-(hydroxymethyl)phenyl)propionic acid
There total 7 articles about (RS)-2-amino-3-(2-(2-carboxyethyl)-5-(hydroxymethyl)phenyl)propionic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen bromide;
In
water;
for 3h;
Reflux;
DOI:10.1021/jm200862h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen bromide / acetic acid / 18 h / 110 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 5 °C / Inert atmosphere
2.2: 16 h / 20 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 2 h / 80 °C
4.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / Reflux
5.1: hydrogen bromide / water / 3 h / Reflux
With
N-Bromosuccinimide; hydrogen bromide; sodium hydride; dibenzoyl peroxide;
In
tetrachloromethane; water; acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200862h
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 20 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: titanium tetrachloride / dichloromethane / 2.5 h / 0 °C / Inert atmosphere
3.1: hydrogen bromide / acetic acid / 18 h / 110 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 5 °C / Inert atmosphere
4.2: 16 h / 20 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide / 2 h / 80 °C
6.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 1 h / Reflux
7.1: hydrogen bromide / water / 3 h / Reflux
With
N-Bromosuccinimide; hydrogen bromide; titanium tetrachloride; sodium hydride; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide;
In
tetrachloromethane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200862h
