Ethyl 1-(2-aminoethyl)-3-piperidinecarboxylate

Base Information

• Chemical Name: Ethyl 1-(2-aminoethyl)-3-piperidinecarboxylate
• CAS No.: 1221792-32-0
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.281
• Hs Code.: 2933399990
• Mol file: 1221792-32-0.mol

Synonyms:

Chemical Property of Ethyl 1-(2-aminoethyl)-3-piperidinecarboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 1-(2-aminoethyl)piperidine-3-carboxylate 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 1-(2-aminoethyl)-3-piperidinecarboxylate

There total 2 articles about Ethyl 1-(2-aminoethyl)-3-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (R)-1-{2-[(tert-butoxycarbonyl)amino]ethyl}piperidine-3-carboxylate (721452-50-2) → C10H20N2O2 (1221792-32-0)

Guidance literature:

ethyl (R)-1-{2-[(tert-butoxycarbonyl)amino]ethyl}piperidine-3-carboxylate; With hydrogenchloride; ethanol; In ethyl acetate; at 0 - 20 ℃;

With potassium hydroxide; In ethanol; water; ethyl acetate; at 0 ℃; pH=~ 10;

Reference yield:

2-bromoethylamine hydrobromide (2576-47-8) + Ethyl nipecotate (71962-74-8) → ethyl 1-(2-aminoethyl) piperidine-3-carboxylate (1221792-32-0)

Guidance literature:

With potassium carbonate; potassium iodide; In 1,4-dioxane; for 30h; Reflux;

DOI:10.1007/s00044-018-2141-9

Reference yield:

ethyl 1-(2-aminoethyl) piperidine-3-carboxylate (1221792-32-0) → 1-(2-(benzylideneamino)ethyl)piperidine-3-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 20 °C

2: acetic acid / ethanol / Reflux

With acetic acid; sodium hydroxide; In ethanol;

DOI:10.1007/s00044-018-2141-9

upstream raw materials:

ethyl (R)-1-{2-[(tert-butoxycarbonyl)amino]ethyl}piperidine-3-carboxylate

2-bromoethylamine hydrobromide

Ethyl nipecotate