C₂₅H₃₂N₂O₃

Base Information

• Chemical Name: C₂₅H₃₂N₂O₃
• CAS No.: 1227244-16-7
• Molecular Formula: C₂₅H₃₂N₂O₃
• Molecular Weight: 408.541
• Mol file: 1227244-16-7.mol

Synonyms:

Chemical Property of C₂₅H₃₂N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₃₂N₂O₃

There total 5 articles about C₂₅H₃₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-iodobenzoate (619-44-3) → C25H32N2O3 (1227244-16-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 5 h / 20 °C / Cooling with ice

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 110 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / ethyl acetate / 1 h / 20 °C

4: acetic acid / 0.25 h / 20 °C

With sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethyl acetate; toluene;

DOI:10.1021/ml300055n

Reference yield:

4-iodobenzoic acid (619-58-9) → C25H32N2O3 (1227244-16-7)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / 1 h / 70 °C

2: sulfuric acid; nitric acid / 5 h / 20 °C / Cooling with ice

3: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 110 °C / Inert atmosphere

4: palladium on activated charcoal; hydrogen / ethyl acetate / 1 h / 20 °C

5: acetic acid / 0.25 h / 20 °C

With thionyl chloride; sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethyl acetate; toluene;

DOI:10.1021/ml300055n

Reference yield:

3-nitro-4-[N-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)amino]benzoic acid methyl ester (1227244-08-7) → C25H32N2O3 (1227244-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / ethyl acetate / 1 h / 20 °C

2: acetic acid / 0.25 h / 20 °C

With palladium on activated charcoal; hydrogen; acetic acid; In ethyl acetate;

DOI:10.1021/ml300055n

upstream raw materials:

3-nitro-4-[N-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)amino]benzoic acid methyl ester

3-amino-4-[N-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)amino]benzoic acid methyl ester

acetic anhydride

4-iodobenzoic acid