Technology Process of methyl (S)-3-phenyl-2-{(1S,2S,3R,5S)-2,6,6-trimethyl-2-[(S)-pyrrolidin-2-ylcarboxamido]bicyclo[3.1.1]heptan-3-ylcarboxamido}propanoate
There total 8 articles about methyl (S)-3-phenyl-2-{(1S,2S,3R,5S)-2,6,6-trimethyl-2-[(S)-pyrrolidin-2-ylcarboxamido]bicyclo[3.1.1]heptan-3-ylcarboxamido}propanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium sulfite / 2 h
2.1: dmap / acetonitrile / 12 h / 20 °C
3.1: lithium hydroxide; water / tetrahydrofuran / 12 h / 20 °C
4.1: triethylamine; isobutyl chloroformate / tetrahydrofuran; dichloromethane / 1 h / -10 °C / Inert atmosphere
4.2: 20 h / -10 - 20 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
6.1: triethylamine / dichloromethane / 18 h / -20 - 20 °C
7.1: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr
With
dmap; palladium 10% on activated carbon; water; hydrogen; triethylamine; trifluoroacetic acid; lithium hydroxide; sodium sulfite; isobutyl chloroformate;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1055/s-0033-1339291
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
2: triethylamine / dichloromethane / 18 h / -20 - 20 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr
With
palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane;
DOI:10.1055/s-0033-1339291
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran; dichloromethane / 1 h / -10 °C / Inert atmosphere
1.2: 20 h / -10 - 20 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
3.1: triethylamine / dichloromethane / 18 h / -20 - 20 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr
With
palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; isobutyl chloroformate;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-0033-1339291
