(2R)-2-iodo-n-hexadecanal

Base Information

• Chemical Name: (2R)-2-iodo-n-hexadecanal
• CAS No.: 180797-62-0
• Molecular Formula: C₁₆H₃₁IO
• Molecular Weight: 366.326
• Mol file: 180797-62-0.mol

Synonyms:

Chemical Property of (2R)-2-iodo-n-hexadecanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-iodo-n-hexadecanal

There total 4 articles about (2R)-2-iodo-n-hexadecanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-1,1-dimethoxy-2-iodo-n-hexadecane (180797-60-8) → (2R)-2-iodo-n-hexadecanal (180797-62-0,130770-02-4)

Guidance literature:

With 70percent aq. CF₃CO₂; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/0040-4020(96)00582-0

Reference yield:

{(1R,3R)-3-[((E)-Hexadec-1-enyl)oxy]-1-isopropyl-4-methyl-pentyloxy}-trimethyl-silane → (2R)-2-iodo-n-hexadecanal (180797-62-0,130770-02-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / ICl / tetrahydrofuran / 0.5 h / -60 °C

2: p-TsOH / 23 h / 50 °C

3: 70percent aq. CF₃CO₂ / CH₂Cl₂ / 1 h / 0 °C

With Iodine monochloride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4020(96)00582-0

Reference yield:

(1'R,4R,6R)-2-(1'-iodo-n-pentadecyl)-4,6-diisopropyl-1,3-dioxane → (2R)-2-iodo-n-hexadecanal (180797-62-0,130770-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TsOH / 23 h / 50 °C

2: 70percent aq. CF₃CO₂ / CH₂Cl₂ / 1 h / 0 °C

With toluene-4-sulfonic acid; In dichloromethane;

DOI:10.1016/0040-4020(96)00582-0

upstream raw materials:

(2R)-1,1-dimethoxy-2-iodo-n-hexadecane

Downstream raw materials:

(2R)-2-iodo-n-hexadecan-1-ol

Refernces