4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbohydrazide

Base Information

• Chemical Name: 4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbohydrazide
• CAS No.: 263387-25-3
• Molecular Formula: C₁₂H₁₀F₃N₃OS
• Molecular Weight: 301.292
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID101326638
• ChEMBL ID: CHEMBL1569210
• Mol file: 263387-25-3.mol

Synonyms:4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbohydrazide;263387-25-3;4-Methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide;Maybridge1_008845;MLS000834869;CHEMBL1569210;HMS566K01;GTNNCFHYKFAPEM-UHFFFAOYSA-N;DTXSID101326638;HMS2779M13;CCG-48418;MFCD00112085;AKOS005069359;SMR000461385;CS-0328191;10Z-0701;SR-01000637960-1

Chemical Property of 4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbohydrazide

Chemical Property:

• Melting Point: 170-173°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 301.04966761
• Heavy Atom Count: 20
• Complexity: 358

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NN

Technology Process of 4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbohydrazide

There total 2 articles about 4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester (175277-03-9) → 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide (263387-25-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux;

DOI:10.3390/molecules200917325

Reference yield:

4-trifluoromethylbenzthioamide (72505-21-6) → 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide (263387-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 5 h / Reflux

2: hydrazine hydrate / ethanol / 5 h / Reflux

With hydrazine hydrate; In ethanol; 1: |Hantzsch Thiazole Synthesis;

DOI:10.3390/molecules200917325

upstream raw materials:

4-trifluoromethylbenzthioamide

4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester

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