alflutinib

Base Information

Chemical Name:alflutinib
CAS No.:1869057-83-9
Molecular Formula:C₂₈H₃₁F₃N₈O₂
Molecular Weight:568.602
Hs Code.:

Synonyms:

Suppliers and Price of alflutinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Alflutinib >98%
250 mg
$ 1600.00

DC Chemicals
Alflutinib >98%
1 g
$ 3200.00

DC Chemicals
Alflutinib >98%
100 mg
$ 850.00

Biorbyt Ltd
Alflutinib >98%
1 g
$ 4766.80

Biorbyt Ltd
Alflutinib >98%
250 mg
$ 2395.30

Biorbyt Ltd
Alflutinib >98%
100 mg
$ 1283.50

Total 4 raw suppliers

Chemical Property of alflutinib

Chemical Property:

Density:1.29±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

Alflutinib >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of alflutinib

There total 5 articles about alflutinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: N²-methyl-N²-[2-(dimethylamino)ethyl]-6-(2,2,2-trifluoroethoxyl)-N⁵-[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]pyridin-2,3,5-triamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1869057-83-9
alflutinib

Guidance literature:: In dichloromethane; for 1.5h; Cooling with ice;

Reference yield: 23.0%

: 1869057-83-9
alflutinib

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Cooling with ice;

Reference yield:

: N²-methyl-N²-[2-(dimethylamino)ethyl]-6-(2,2,2-trifluoroethoxy)-3-nitropyridine-2,5-di amine

: 1869057-83-9
alflutinib

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 5 h / 95 °C / Inert atmosphere

2: platinum(IV) oxide; hydrogen / methanol / 1 h / 20 °C

3: dichloromethane / 1.5 h / Cooling with ice

With platinum(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane;