Technology Process of methyl 4-<(di-tert-butylphosphono)fluoromethyl>-D,L-phenylalaninate
There total 7 articles about methyl 4-<(di-tert-butylphosphono)fluoromethyl>-D,L-phenylalaninate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) NaH / 1) THF, oil, -78 deg C, 40 min, 2) 0 deg C to rt, 2.5 h
2: 1 N HCl / CHCl3 / Ambient temperature
3: 57 percent / NaOMe / 1) -78 deg C, 5 min, 2) 0 deg C, 1 h
4: 92 percent / H2 / 10percent Pd/C / methanol / 3 h / 2068.6 Torr
5: 85 percent / Et3N / tetrahydrofuran / 0.33 h / 0 °C
6: 69 percent / Et2NSF3 / CHCl3 / 1) -78 deg C, 10 min, 2) rt, 20 min
7: 85 percent / H2 / 10percent Pd/C / methanol / 2482.3 Torr
With
hydrogenchloride; diethylamino-sulfur trifluoride; hydrogen; sodium methylate; sodium hydride; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jo00058a009
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) NaH / 1) THF, oil, -78 deg C, 40 min, 2) 0 deg C to rt, 2.5 h
2: 1 N HCl / CHCl3 / Ambient temperature
3: 57 percent / NaOMe / 1) -78 deg C, 5 min, 2) 0 deg C, 1 h
4: 92 percent / H2 / 10percent Pd/C / methanol / 3 h / 2068.6 Torr
5: 85 percent / Et3N / tetrahydrofuran / 0.33 h / 0 °C
6: 69 percent / Et2NSF3 / CHCl3 / 1) -78 deg C, 10 min, 2) rt, 20 min
7: 85 percent / H2 / 10percent Pd/C / methanol / 2482.3 Torr
With
hydrogenchloride; diethylamino-sulfur trifluoride; hydrogen; sodium methylate; sodium hydride; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jo00058a009
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 57 percent / NaOMe / 1) -78 deg C, 5 min, 2) 0 deg C, 1 h
2: 92 percent / H2 / 10percent Pd/C / methanol / 3 h / 2068.6 Torr
3: 85 percent / Et3N / tetrahydrofuran / 0.33 h / 0 °C
4: 69 percent / Et2NSF3 / CHCl3 / 1) -78 deg C, 10 min, 2) rt, 20 min
5: 85 percent / H2 / 10percent Pd/C / methanol / 2482.3 Torr
With
diethylamino-sulfur trifluoride; hydrogen; sodium methylate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jo00058a009
