(R)-(-)-2,2-ethylenedioxy-8-methyldecane

Base Information

• Chemical Name: (R)-(-)-2,2-ethylenedioxy-8-methyldecane
• CAS No.: 104435-14-5
• Molecular Formula: C₁₃H₂₆O₂
• Molecular Weight: 214.348
• Mol file: 104435-14-5.mol

Synonyms:

Chemical Property of (R)-(-)-2,2-ethylenedioxy-8-methyldecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-2,2-ethylenedioxy-8-methyldecane

There total 3 articles about (R)-(-)-2,2-ethylenedioxy-8-methyldecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-magnesium chloride (62026-31-7) + (R)-(-)-3-methylpentyl-bromide (90410-57-4) → (R)-(-)-2,2-ethylenedioxy-8-methyldecane (104435-14-5)

Guidance literature:

With copper(l) iodide; In tetrahydrofuran; 1.) -10 deg C, 1 h, 2.) 20-25 deg C, 4 h;

DOI:10.1007/BF00958349

Reference yield: 88.0%

(R)-(-)-1-tosyloxy-4-methylhexane (71777-31-6) + 2-(2-methyl-1,3-dioxolan-2-yl)ethylmagnesium bromide → (R)-(-)-2,2-ethylenedioxy-8-methyldecane (104435-14-5)

Guidance literature:

With dilithium tetrachlorocuprate; In tetrahydrofuran; diethyl ether; 1.) -70 deg C, 1 h, 2.) 20 deg C, 4 h;

DOI:10.1007/BF00958349

Reference yield:

(R)-(-)-4-methyl-1-hexanol (53353-04-1) → (R)-(-)-2,2-ethylenedioxy-8-methyldecane (104435-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) pyridine, 0-5 deg C, 5 h, 2.) 100 deg C, 2 mm, 1 h

2: 88 percent / Li₂CuCl₄ / diethyl ether; tetrahydrofuran / 1.) -70 deg C, 1 h, 2.) 20 deg C, 4 h

With dilithium tetrachlorocuprate; In tetrahydrofuran; diethyl ether;

DOI:10.1007/BF00958349

upstream raw materials:

(R)-(-)-1-tosyloxy-4-methylhexane

[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-magnesium chloride

(R)-(-)-3-methylpentyl-bromide

(R)-(-)-4-methyl-1-hexanol

Downstream raw materials:

(2RS,8R)-(-)-2-propionoxy-8-methyldecane