(2R,5S)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-7-oxo-6-oxa-8-azaspiro[4.5]decane-2-carboxamide

Base Information

Chemical Name:(2R,5S)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-7-oxo-6-oxa-8-azaspiro[4.5]decane-2-carboxamide
CAS No.:1287746-08-0
Molecular Formula:C₂₇H₃₈ClN₃O₅
Molecular Weight:520.069
Hs Code.:

(2R,5S)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-7-oxo-6-oxa-8-azaspiro[4.5]decane-2-carboxamide

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Chemical Property of (2R,5S)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-7-oxo-6-oxa-8-azaspiro[4.5]decane-2-carboxamide

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Technology Process of (2R,5S)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-7-oxo-6-oxa-8-azaspiro[4.5]decane-2-carboxamide

There total 2 articles about (2R,5S)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-7-oxo-6-oxa-8-azaspiro[4.5]decane-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287745-32-7
(R)-benzyl 3-oxocyclopentanecarboxylate

: 1287746-06-8
(2R,5R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-7-oxo-6-oxa-8-azaspiro[4.5]decane-2-carboxamide

: 1287746-08-0
(2R,5S)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-7-oxo-6-oxa-8-azaspiro[4.5]decane-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc; ammonium chloride / tetrahydrofuran / 20 - 80 °C

2.1: ozone / dichloromethane / -78 °C

3.1: trifluoroacetic acid; triethylsilane; tert-butyl carbazate / acetonitrile / 4 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: water; methanol

5.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

6.1: hydrogen / palladium on carbon / methanol / 0.5 h

7.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 16 h / 20 °C

With triethylsilane; tert-butyl carbazate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; ozone; triethylamine; trifluoroacetic acid; zinc; palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1287745-74-7
(1R)-benzyl 3-allyl-3-hydroxycyclopentanecarboxylate

: 1287746-06-8
(2R,5R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-7-oxo-6-oxa-8-azaspiro[4.5]decane-2-carboxamide

: 1287746-08-0
(2R,5S)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-7-oxo-6-oxa-8-azaspiro[4.5]decane-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ozone / dichloromethane / -78 °C

2.1: trifluoroacetic acid; triethylsilane; tert-butyl carbazate / acetonitrile / 4 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: water; methanol

4.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

5.1: hydrogen / palladium on carbon / methanol / 0.5 h

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 16 h / 20 °C

With triethylsilane; tert-butyl carbazate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ozone; triethylamine; trifluoroacetic acid; palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;