ethyl 2-(2-morpholinoacetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Base Information

• Chemical Name: ethyl 2-(2-morpholinoacetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
• CAS No.: 62349-05-7
• Molecular Formula: C₁₇H₂₄N₂O₄S
• Molecular Weight: 352.455

Synonyms:Benzo[b]thiophene-3-carboxylicacid, 4,5,6,7-tetrahydro-2-[(4-morpholinylacetyl)amino]-, ethyl ester (9CI)

Chemical Property of ethyl 2-(2-morpholinoacetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Chemical Property:

• Vapor Pressure: 3.13E-13mmHg at 25°C
• Boiling Point: 575.1°C at 760 mmHg
• Flash Point: 301.6°C
• PSA: 99.60000
• Density: 1.268g/cm³
• LogP: 2.66170

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(2-morpholinoacetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

There total 5 articles about ethyl 2-(2-morpholinoacetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

morpholine (110-91-8,99108-56-2) + 2-chloroacetylamino-3-carbethoxy-4,5,6,7-tetrahydrobenzothiophene (60442-41-3) → ethyl 2-[(2-morpholinoacetyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate (62349-05-7)

Guidance literature:

2-chloroacetylamino-3-carbethoxy-4,5,6,7-tetrahydrobenzothiophene; With sodium iodide; In acetone; at 20 ℃; for 15h;

morpholine; With tetra-(n-butyl)ammonium iodide; triethylamine; In acetonitrile; at 100 ℃; for 4h;

DOI:10.1002/anie.201411206

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → ethyl 2-[(2-morpholinoacetyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate (62349-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / acetic acid / 3 h / Heating

2: 57 percent / dioxane / 4 h / Heating

In 1,4-dioxane; acetic acid;

Reference yield:

ethyl 2-cyano-2-cyclohexylideneacetate (6802-76-2) → ethyl 2-[(2-morpholinoacetyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate (62349-05-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sulphur, diethylamine / ethanol / 50 °C

2: 63 percent / acetic acid / 3 h / Heating

3: 57 percent / dioxane / 4 h / Heating

With sulfur; diethylamine; In 1,4-dioxane; ethanol; acetic acid;

upstream raw materials:

morpholine

2-chloroacetylamino-3-carbethoxy-4,5,6,7-tetrahydrobenzothiophene

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

ethyl 2-cyano-2-cyclohexylideneacetate

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