[6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester

Base Information

• Chemical Name: [6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester
• CAS No.: 175354-88-8
• Molecular Formula: C₅₂H₅₇N₆O₁₂PSi
• Molecular Weight: 1017.12

Synonyms:

Chemical Property of [6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester

There total 7 articles about [6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphanyloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester (1053648-85-3) → [6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester (175354-88-8)

Guidance literature:

With tert.-butylhydroperoxide; In 2,2,4-trimethylpentane; Yield given;

DOI:10.1021/jo951593c

Reference yield:

2-(3,5-dimethoxyphenyl)-2-hydroxy-1-phenylethan-1-one (34904-92-2) → [6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester (175354-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-tetrazole / acetonitrile

2: t-BuOOH / 2,2,4-trimethyl-pentane

With 1H-tetrazole; tert.-butylhydroperoxide; In 2,2,4-trimethylpentane; acetonitrile;

DOI:10.1021/jo951593c

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → [6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester (175354-88-8)

Guidance literature:

Multi-step reaction with 4 steps

1: Py

2: EtNiPr₂ / CH₂Cl₂ / 1 h

3: 1H-tetrazole / acetonitrile

4: t-BuOOH / 2,2,4-trimethyl-pentane

With pyridine; 1H-tetrazole; tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; In 2,2,4-trimethylpentane; dichloromethane; acetonitrile;

DOI:10.1021/jo951593c

upstream raw materials:

[6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphanyloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester

2-(3,5-dimethoxyphenyl)-2-hydroxy-1-phenylethan-1-one

tert-butylchlorodiphenylsilane

O⁶-Allyl-N²-(allyloxycarbonyl)-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 175354-88-8 [6-Allyloxy-9-((2R,4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-{(2-cyano-ethoxy)-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethoxy]-phosphoryloxy}-tetrahydro-furan-2-yl)-9H-purin-2-yl]-carbamic acid allyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send