(S)-{2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetoxy}-phenyl-acetic acid; compound with (R)-1-isopropylamino-3-((R)-3-nitrooxy-chroman-8-yloxy)-propan-2-ol

Base Information

• Chemical Name: (S)-{2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetoxy}-phenyl-acetic acid; compound with (R)-1-isopropylamino-3-((R)-3-nitrooxy-chroman-8-yloxy)-propan-2-ol
• CAS No.: 100922-10-9
• Molecular Formula: C₁₅H₂₂N₂O₆*C₂₇H₂₂ClNO₆
• Molecular Weight: 818.277
• Mol file: 100922-10-9.mol

Synonyms:

Chemical Property of (S)-{2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetoxy}-phenyl-acetic acid; compound with (R)-1-isopropylamino-3-((R)-3-nitrooxy-chroman-8-yloxy)-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-{2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetoxy}-phenyl-acetic acid; compound with (R)-1-isopropylamino-3-((R)-3-nitrooxy-chroman-8-yloxy)-propan-2-ol

There total 3 articles about (S)-{2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetoxy}-phenyl-acetic acid; compound with (R)-1-isopropylamino-3-((R)-3-nitrooxy-chroman-8-yloxy)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → (S)-{2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetoxy}-phenyl-acetic acid; compound with (R)-1-isopropylamino-3-((R)-3-nitrooxy-chroman-8-yloxy)-propan-2-ol (100922-10-9)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / dioxane / 0.5 h / Heating

2: dioxane / 0.5 h / Heating

3: ethyl acetate; hexane / Ambient temperature

With thionyl chloride; In 1,4-dioxane; hexane; ethyl acetate;

DOI:10.1248/cpb.33.2735

Reference yield:

1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride (20357-37-3) → (S)-{2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetoxy}-phenyl-acetic acid; compound with (R)-1-isopropylamino-3-((R)-3-nitrooxy-chroman-8-yloxy)-propan-2-ol (100922-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane / 0.5 h / Heating

2: ethyl acetate; hexane / Ambient temperature

In 1,4-dioxane; hexane; ethyl acetate;

DOI:10.1248/cpb.33.2735

Reference yield:

(S)-1-Isopropylamino-3-((S)-3-nitrooxy-chroman-8-yloxy)-propan-2-ol (81486-22-8,99257-23-5,99257-24-6,100570-65-8,100570-66-9,100570-67-0,100570-68-1) + (+)-2-<1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl>acetoxy-2-phenylacetic acid (100921-91-3) → (S)-{2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetoxy}-phenyl-acetic acid; compound with (R)-1-isopropylamino-3-((R)-3-nitrooxy-chroman-8-yloxy)-propan-2-ol (100922-10-9)

Guidance literature:

In hexane; ethyl acetate; Ambient temperature;

DOI:10.1248/cpb.33.2735

upstream raw materials:

(S)-1-Isopropylamino-3-((S)-3-nitrooxy-chroman-8-yloxy)-propan-2-ol

(+)-2-<1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl>acetoxy-2-phenylacetic acid

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride