6-N-benzoyl-5'-O-[di(2-cyanoethoxy)phosphinyl]-P-(2-cyanoethyl)-1'-deoxy-2'-isoadenylyl-(3'->5')-4-N,2'-O,3'-O-tribenzoylcytidine

Base Information

• Chemical Name: 6-N-benzoyl-5'-O-[di(2-cyanoethoxy)phosphinyl]-P-(2-cyanoethyl)-1'-deoxy-2'-isoadenylyl-(3'->5')-4-N,2'-O,3'-O-tribenzoylcytidine
• CAS No.: 917598-89-1
• Molecular Formula: C₅₆H₅₁N₁₁O₁₇P₂
• Molecular Weight: 1212.03
• Mol file: 917598-89-1.mol

Synonyms:

Chemical Property of 6-N-benzoyl-5'-O-[di(2-cyanoethoxy)phosphinyl]-P-(2-cyanoethyl)-1'-deoxy-2'-isoadenylyl-(3'->5')-4-N,2'-O,3'-O-tribenzoylcytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-N-benzoyl-5'-O-[di(2-cyanoethoxy)phosphinyl]-P-(2-cyanoethyl)-1'-deoxy-2'-isoadenylyl-(3'->5')-4-N,2'-O,3'-O-tribenzoylcytidine

There total 9 articles about 6-N-benzoyl-5'-O-[di(2-cyanoethoxy)phosphinyl]-P-(2-cyanoethyl)-1'-deoxy-2'-isoadenylyl-(3'->5')-4-N,2'-O,3'-O-tribenzoylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C56H51N11O16P2 → 6-N-benzoyl-5'-O-[di(2-cyanoethoxy)phosphinyl]-P-(2-cyanoethyl)-1'-deoxy-2'-isoadenylyl-(3'->5')-4-N,2'-O,3'-O-tribenzoylcytidine (917598-89-1)

Guidance literature:

With pyridine; iodine; In tetrahydrofuran; water;

DOI:10.1080/15257770500265703

Reference yield:

6-N-benzoyl-1'-deoxy-2'-isoadenosine → 6-N-benzoyl-5'-O-[di(2-cyanoethoxy)phosphinyl]-P-(2-cyanoethyl)-1'-deoxy-2'-isoadenylyl-(3'->5')-4-N,2'-O,3'-O-tribenzoylcytidine (917598-89-1)

Guidance literature:

Multi-step reaction with 6 steps

1: pyridine / 2 h

2: 1H-tetrazole / CH₂Cl₂

3: I₂; pyridine / H₂O; tetrahydrofuran

4: dichloroacetic acid / CH₂Cl₂

5: 1H-tetrazole / CH₂Cl₂ / 20 °C

6: I₂; pyridine / H₂O; tetrahydrofuran

With pyridine; 1H-tetrazole; dichloro-acetic acid; iodine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1080/15257770500265703

Reference yield:

N4-benzoyl-2',3'-O-dibenzoylcytidine-5'-O-[β-cyanoethyl-N,N-diisopropyl]-phosphoramidite (669772-59-2) → 6-N-benzoyl-5'-O-[di(2-cyanoethoxy)phosphinyl]-P-(2-cyanoethyl)-1'-deoxy-2'-isoadenylyl-(3'->5')-4-N,2'-O,3'-O-tribenzoylcytidine (917598-89-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 1H-tetrazole / CH₂Cl₂

2: I₂; pyridine / H₂O; tetrahydrofuran

3: dichloroacetic acid / CH₂Cl₂

4: 1H-tetrazole / CH₂Cl₂ / 20 °C

5: I₂; pyridine / H₂O; tetrahydrofuran

With pyridine; 1H-tetrazole; dichloro-acetic acid; iodine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1080/15257770500265703

upstream raw materials:

N⁴-benzoyl-2',3'-O-dibenzoylcytidine-5'-O-[β-cyanoethyl-N,N-diisopropyl]-phosphoramidite

6-N-benzoyl-P-(2-cyanoethyl)-1'-deoxy-2'-isoadenylyl-(3'->5')-4-N,2'-O,3'-O-tribenzoylcytidine

bis(2-cyanoethyl) diisopropylamidophosphite

N,2',3'-O-tribenzoylcytidine