C₄₅H₆₆O₅Si₂

Base Information

• Chemical Name: C₄₅H₆₆O₅Si₂
• CAS No.: 1429412-54-3
• Molecular Formula: C₄₅H₆₆O₅Si₂
• Molecular Weight: 743.187
• Mol file: 1429412-54-3.mol

Synonyms:

Chemical Property of C₄₅H₆₆O₅Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₅H₆₆O₅Si₂

There total 25 articles about C₄₅H₆₆O₅Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

C34H57NO5Si2 (1429412-51-0) + C13H16O (1429412-53-2) → C45H66O5Si2 (1429412-54-3) + C33H53NO4Si2

Guidance literature:

With n-butyllithium; In tetrahydrofuran;

DOI:10.1039/c3ob27508f

Reference yield:

ethyl diethyl malonate (133-13-1) → C45H66O5Si2 (1429412-54-3)

Guidance literature:

Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 16.5 h / -10 - 20 °C

2.1: sodium hydride / nujol; tetrahydrofuran / 16.5 h / 0 - 20 °C

2.2: 3 h / 0 - 20 °C

3.1: Amano lipase / di-isopropyl ether / 12 h / 20 °C / Enzymatic reaction

4.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 16 h / 0 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C

6.2: -78 - 20 °C

7.1: potassium carbonate / methanol / 8 h / 20 °C

8.1: n-butyllithium / tetrahydrofuran

With lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; trifluorormethanesulfonic acid; Amano lipase; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; dimethyl sulfoxide; In tetrahydrofuran; methanol; nujol; dichloromethane; di-isopropyl ether; cyclohexane; 6.1: |Swern Oxidation / 6.2: |Swern Oxidation;

DOI:10.1039/c3ob27508f

Reference yield:

2-(((tert-butyldiphenylsilyl)oxy)methyl)butan-1-ol (1394253-59-8) → C45H66O5Si2 (1429412-54-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Amano lipase / di-isopropyl ether / 12 h / 20 °C / Enzymatic reaction

2.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 16 h / 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C

4.2: -78 - 20 °C

5.1: potassium carbonate / methanol / 8 h / 20 °C

6.1: n-butyllithium / tetrahydrofuran

With n-butyllithium; oxalyl dichloride; trifluorormethanesulfonic acid; Amano lipase; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; In tetrahydrofuran; methanol; dichloromethane; di-isopropyl ether; cyclohexane; 4.1: |Swern Oxidation / 4.2: |Swern Oxidation;

DOI:10.1039/c3ob27508f

upstream raw materials:

C₂₈H₃₈O₅Si

C₂₆H₃₆O₅Si

C₂₅H₃₂O₄Si

2,2-Dimethyl-1,3-propanediol

Refernces