C₂HF₃O₂*C₄₅H₄₇N₇O₆S

Base Information

• Chemical Name: C₂HF₃O₂*C₄₅H₄₇N₇O₆S
• CAS No.: 1354577-82-4
• Molecular Formula: C₂HF₃O₂*C₄₅H₄₇N₇O₆S
• Molecular Weight: 928.001
• Mol file: 1354577-82-4.mol

Synonyms:

Chemical Property of C₂HF₃O₂*C₄₅H₄₇N₇O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂HF₃O₂*C₄₅H₄₇N₇O₆S

There total 17 articles about C₂HF₃O₂*C₄₅H₄₇N₇O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-Phe(3-CN)-OH*HCl (600708-39-2) → C2HF3O2*C45H47N7O6S (1354577-82-4)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 6 h / 0 - 20 °C / pH 8 - 9

2.1: palladium 10% on activated carbon / 40 °C

3.1: 4-methyl-morpholine / acetonitrile / Cooling with ice

4.1: dichloromethane / 1 h

5.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Reflux

5.2: 20 °C / pH 8 - 9 / Cooling with ice

6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 7 - 8 h / Cooling with ice

7.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C

8.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Cooling with ice

9.1: water; sodium hydroxide / ethanol / 2 h / 20 °C

10.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Cooling with ice

With 4-methyl-morpholine; chloro-trimethyl-silane; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm2011996

Reference yield:

C44H46N4O9S (1354578-35-0) → C2HF3O2*C45H47N7O6S (1354577-82-4)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen bromide; acetic acid / 1.5 h / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Cooling with ice

3: water; sodium hydroxide / ethanol / 2 h / 20 °C

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Cooling with ice

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm2011996

Reference yield:

Boc-D-3-cyanophenylalanine → C2HF3O2*C45H47N7O6S (1354577-82-4)

Guidance literature:

Multi-step reaction with 9 steps

1.1: palladium 10% on activated carbon / 40 °C

2.1: 4-methyl-morpholine / acetonitrile / Cooling with ice

3.1: dichloromethane / 1 h

4.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Reflux

4.2: 20 °C / pH 8 - 9 / Cooling with ice

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 7 - 8 h / Cooling with ice

6.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C

7.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Cooling with ice

8.1: water; sodium hydroxide / ethanol / 2 h / 20 °C

9.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Cooling with ice

With 4-methyl-morpholine; chloro-trimethyl-silane; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm2011996

upstream raw materials:

(S)-2-((tert-butoxycarbonyl)amino)-3-(3-cyanophenyl)propanoic acid

D-Phe(3-CN)-OH*HCl

Boc-D-Phe(4-AMe)-OH*CH₃COOH

Boc-D-Phe(4-AMe)-OH*CH₃COOH