Lorglumide, (R)-

Base Information

Chemical Name:Lorglumide, (R)-
CAS No.:118919-27-0
Molecular Formula:C22H32Cl2N2O4
Molecular Weight:459.413
Hs Code.:
UNII:IF62287E88
ChEMBL ID:CHEMBL9485
Nikkaji Number:J259.905H
Wikidata:Q27280698
Mol file:118919-27-0.mol

Synonyms:Lorglumide, (R)-;IF62287E88;CHEMBL9485;UNII-IF62287E88;118919-27-0;Pentanoic acid, 4-((3,4-dichlorobenzoyl)amino)-5-(dipentylamino)-5-oxo-, (R)-;(R)-lorglumide;4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-butyric acid;BDBM50005459;AKOS000278178;PD119671;Q27280698

Suppliers and Price of Lorglumide, (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Lorglumide, (R)-

Chemical Property:

XLogP3:5.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:14
Exact Mass:458.1739129
Heavy Atom Count:30
Complexity:537

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC(=C(C=C1)Cl)Cl
Isomeric SMILES:CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)C1=CC(=C(C=C1)Cl)Cl

Technology Process of Lorglumide, (R)-

There total 13 articles about Lorglumide, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.7%

: 104252-86-0
3,4-Dichloro-N-(2,6-dioxo-tetrahydro-pyran-3-yl)-benzamide

: 2050-92-2
Di-n-amylamine

: 118919-27-0,118919-28-1,97964-56-2
lorglumide

: 102743-06-6
2-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-butyric acid

Guidance literature:: In water; at 5 - 10 ℃; for 3h;

Reference yield:

: 2050-92-2
Di-n-amylamine

: 118919-27-0
(R)-Lorglumide

Guidance literature:: Multi-step reaction with 4 steps

1: / CH₂Cl₂ / -20 to 0 deg C

2: HCl / dioxane / 0 - 5 °C

3: tetrahydrofuran

4: cyclohexadiene / 10 percent Pd/C / ethanol

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; cyclohexa-1,3-diene; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm00124a003