Technology Process of (R)-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]-benzodioxole-7,3'-indol]-2'(1'H)-one
There total 9 articles about (R)-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]-benzodioxole-7,3'-indol]-2'(1'H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Chiralcel OJ-RH;
In
water; acetonitrile;
at 20 ℃;
for 1h;
Resolution of racemate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 0 - 4 °C / Industry scale
1.2: -5 - 3 °C / Industry scale
1.3: 3 - 4 °C / Industry scale
2.1: trifluoroacetic acid / 1.33 h / 10 °C / Inert atmosphere; Industry scale
2.2: 2.58 h / 10 - 11 °C / Industry scale; Inert atmosphere
3.1: water / 5 °C / Industry scale
3.2: 1.67 h / 5 °C / Industry scale
3.3: 2.33 h / 1 °C / Industry scale
4.1: di-isopropyl azodicarboxylate; tributylphosphine / tetrahydrofuran / 2.5 h / -4 - 0 °C / Industry scale
4.2: 3.75 h / -3 - 25 °C / Industry scale
5.1: caesium carbonate / acetone / Reflux; Industry scale
6.1: Chiralcel.(R). OJ-RH / acetonitrile; water / 20 °C / Resolution of racemate
With
tributylphosphine; di-isopropyl azodicarboxylate; isopropylmagnesium chloride; caesium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; water; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 0 - 4 °C / Industry scale
1.2: -5 - 3 °C / Industry scale
1.3: 3 - 4 °C / Industry scale
2.1: trifluoroacetic acid / 1.33 h / 10 °C / Inert atmosphere; Industry scale
2.2: 2.58 h / 10 - 11 °C / Industry scale; Inert atmosphere
3.1: water / 5 °C / Industry scale
3.2: 1.67 h / 5 °C / Industry scale
3.3: 2.33 h / 1 °C / Industry scale
4.1: di-isopropyl azodicarboxylate; tributylphosphine / tetrahydrofuran / 2.5 h / -4 - 0 °C / Industry scale
4.2: 3.75 h / -3 - 25 °C / Industry scale
5.1: caesium carbonate / acetone / Reflux; Industry scale
6.1: Chiralcel.(R). OJ-RH / acetonitrile; water / 20 °C / Resolution of racemate
With
tributylphosphine; di-isopropyl azodicarboxylate; isopropylmagnesium chloride; caesium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; water; acetone; acetonitrile;
![1'-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one](/Databaselist/images/loading.webp)
