(2R,5R,13'R, 1''R)-2-(1'-tert-butyldiphenylsilyloxy-13'-methoxymethoxytridecyl)-5-(1''-methoxymethoxytridecyl)tetrahydrofuran

Base Information

Chemical Name:(2R,5R,13'R, 1''R)-2-(1'-tert-butyldiphenylsilyloxy-13'-methoxymethoxytridecyl)-5-(1''-methoxymethoxytridecyl)tetrahydrofuran
CAS No.:227186-07-4
Molecular Formula:C₅₀H₈₆O₆Si
Molecular Weight:811.315
Hs Code.:

Synonyms:

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Chemical Property of (2R,5R,13'R, 1''R)-2-(1'-tert-butyldiphenylsilyloxy-13'-methoxymethoxytridecyl)-5-(1''-methoxymethoxytridecyl)tetrahydrofuran

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Technology Process of (2R,5R,13'R, 1''R)-2-(1'-tert-butyldiphenylsilyloxy-13'-methoxymethoxytridecyl)-5-(1''-methoxymethoxytridecyl)tetrahydrofuran

There total 7 articles about (2R,5R,13'R, 1''R)-2-(1'-tert-butyldiphenylsilyloxy-13'-methoxymethoxytridecyl)-5-(1''-methoxymethoxytridecyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143-15-7
1-dodecylbromide

: 227186-07-4
(2R,5R,13'R, 1''R)-2-(1'-tert-butyldiphenylsilyloxy-13'-methoxymethoxytridecyl)-5-(1''-methoxymethoxytridecyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Mg, CuBr*SMe₂ / 1.) Et₂O, r.t., 1 h then -50 deg C, 10 min then -30 deg C, 30 min; 2.) Et₂O, -50 deg C to r.t., overnight

2: 99 percent / DIPEA / CH₂Cl₂ / Ambient temperature

3: 97 percent / Bu₄NF / tetrahydrofuran / 1 h

4: 93 percent / Dess-Martin periodinane / CH₂Cl₂ / 1.5 h

5: 1.) Mg, CuBr*SMe₂ / 1.) Et₂O, r.t., 1 h then -50 deg C, 10 min then -30 deg C, 30 min; 2.) Et₂O, -50 deg C to r.t., overnight

6: DIPEA / CH₂Cl₂ / Ambient temperature

With copper(I) bromide dimethylsulfide complex; tetrabutyl ammonium fluoride; Dess-Martin periodane; magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 206260-14-2
5-(R)-[1-(R)-methoxymethoxy-tridecyl]tetrahydrofuran-2-(R)-carbaldehyde

: 227186-07-4
(2R,5R,13'R, 1''R)-2-(1'-tert-butyldiphenylsilyloxy-13'-methoxymethoxytridecyl)-5-(1''-methoxymethoxytridecyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Mg, CuBr*SMe₂ / 1.) Et₂O, r.t., 1 h then -50 deg C, 10 min then -30 deg C, 30 min; 2.) Et₂O, -50 deg C to r.t., overnight

2: DIPEA / CH₂Cl₂ / Ambient temperature

With copper(I) bromide dimethylsulfide complex; magnesium; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: (2R,5R)-5-[(tert-butyldiphenylsiloxy)methyl]tetrahydrofuran-2-carbaldehyde

: 227186-07-4
(2R,5R,13'R, 1''R)-2-(1'-tert-butyldiphenylsilyloxy-13'-methoxymethoxytridecyl)-5-(1''-methoxymethoxytridecyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Mg, CuBr*SMe₂ / 1.) Et₂O, r.t., 1 h then -50 deg C, 10 min then -30 deg C, 30 min; 2.) Et₂O, -50 deg C to r.t., overnight

2: 99 percent / DIPEA / CH₂Cl₂ / Ambient temperature

3: 97 percent / Bu₄NF / tetrahydrofuran / 1 h

4: 93 percent / Dess-Martin periodinane / CH₂Cl₂ / 1.5 h

5: 1.) Mg, CuBr*SMe₂ / 1.) Et₂O, r.t., 1 h then -50 deg C, 10 min then -30 deg C, 30 min; 2.) Et₂O, -50 deg C to r.t., overnight

6: DIPEA / CH₂Cl₂ / Ambient temperature

With copper(I) bromide dimethylsulfide complex; tetrabutyl ammonium fluoride; Dess-Martin periodane; magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;