methyl 2-(1-methyl-6-phenyl-indol-3-yl)acetate

Base Information

Chemical Name:methyl 2-(1-methyl-6-phenyl-indol-3-yl)acetate
CAS No.:1334298-80-4
Molecular Formula:C₁₈H₁₇NO₂
Molecular Weight:279.338
Hs Code.:

Synonyms:

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Chemical Property of methyl 2-(1-methyl-6-phenyl-indol-3-yl)acetate

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Technology Process of methyl 2-(1-methyl-6-phenyl-indol-3-yl)acetate

There total 5 articles about methyl 2-(1-methyl-6-phenyl-indol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1334298-79-1
methyl 2-(1-methyl-6-chloro-indol-3-yl)acetate

: 98-80-6
phenylboronic acid

: 1334298-80-4
methyl 2-(1-methyl-6-phenyl-indol-3-yl)acetate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In tetrahydrofuran; for 22h; Inert atmosphere; Reflux;
DOI:10.1002/anie.201103151

Reference yield:

: 17422-33-2
6-chloroindole

: 1334298-80-4
methyl 2-(1-methyl-6-phenyl-indol-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether / 0 °C / Reflux; Inert atmosphere

1.2: 0.5 h / Reflux

2.1: hydrazine hydrate / 2-ethoxy-ethanol / 1 h / 60 °C / Inert atmosphere

2.2: 60 - 150 °C / Inert atmosphere

3.1: methanol / 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

5.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / tetrahydrofuran / 22 h / Inert atmosphere; Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; sodium hydride; hydrazine hydrate; In tetrahydrofuran; methanol; 2-ethoxy-ethanol; diethyl ether; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/anie.201103151

Reference yield:

: 929005-85-6
2-oxo-2-(6-chloro-1H-indol-3-yl)acetic acid

: 1334298-80-4
methyl 2-(1-methyl-6-phenyl-indol-3-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / 2-ethoxy-ethanol / 1 h / 60 °C / Inert atmosphere

1.2: 60 - 150 °C / Inert atmosphere

2.1: methanol / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / tetrahydrofuran / 22 h / Inert atmosphere; Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; sodium hydride; hydrazine hydrate; In tetrahydrofuran; methanol; 2-ethoxy-ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/anie.201103151