N-(6-amino-pyridin-2-yl)-N'-[{4-[[3-(6-amino-pyridin-2-ylcarbamoyl)-propionylamino]-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-succinamide

Base Information

• Chemical Name: N-(6-amino-pyridin-2-yl)-N'-[{4-[[3-(6-amino-pyridin-2-ylcarbamoyl)-propionylamino]-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-succinamide
• CAS No.: 928664-04-4
• Molecular Formula: C₃₅H₃₆F₂N₈O₄S₃
• Molecular Weight: 766.917

Synonyms:

Chemical Property of N-(6-amino-pyridin-2-yl)-N'-[{4-[[3-(6-amino-pyridin-2-ylcarbamoyl)-propionylamino]-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-succinamide

Chemical Property:

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Useful:

Technology Process of N-(6-amino-pyridin-2-yl)-N'-[{4-[[3-(6-amino-pyridin-2-ylcarbamoyl)-propionylamino]-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-succinamide

There total 5 articles about N-(6-amino-pyridin-2-yl)-N'-[{4-[[3-(6-amino-pyridin-2-ylcarbamoyl)-propionylamino]-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C45H52F2N8O8S3 → N-(6-amino-pyridin-2-yl)-N'-[{4-[[3-(6-amino-pyridin-2-ylcarbamoyl)-propionylamino]-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-succinamide (928664-04-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ol0700153

Reference yield:

2,4-Bis-[amino-(4-fluorophenyl)-methyl]-[1,3,5]trithiane (928664-01-1) → N-(6-amino-pyridin-2-yl)-N'-[{4-[[3-(6-amino-pyridin-2-ylcarbamoyl)-propionylamino]-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-succinamide (928664-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC; N-hydroxy succinimide; DMAP / CH₂Cl₂ / 1 h

2: trifluoroacetic acid / CH₂Cl₂

With dmap; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ol0700153

Reference yield:

N-(6-tert-butoxycarbonylamino-pyridin-2-yl)-succinamic acid → N-(6-amino-pyridin-2-yl)-N'-[{4-[[3-(6-amino-pyridin-2-ylcarbamoyl)-propionylamino]-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-succinamide (928664-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC; N-hydroxy succinimide; DMAP / CH₂Cl₂ / 1 h

2: trifluoroacetic acid / CH₂Cl₂

With dmap; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ol0700153

upstream raw materials:

2,4-Bis-[amino-(4-fluorophenyl)-methyl]-[1,3,5]trithiane

[{4-[tert-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester

4-fluorobenzaldehyde

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