Aldose reductase-IN-1

Base Information

• Chemical Name: Aldose reductase-IN-1
• CAS No.: 1355612-71-3
• Molecular Formula: C₁₇H₁₀F₃N₅O₃S
• Molecular Weight: 421.359
• Mol file: 1355612-71-3.mol

Synonyms:

Chemical Property of Aldose reductase-IN-1

Chemical Property:

• Boiling Point: 632.1±65.0 °C(Predicted)
• PKA: 2.99±0.10(Predicted)
• Density: 1.74±0.1 g/cm3(Predicted)

Purity/Quality:

99.90% ^*data from raw suppliers

Aldosereductase-IN-1 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Aldose reductase-IN-1

There total 7 articles about Aldose reductase-IN-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

tert-butyl 2-(8-oxo-7-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl)acetate (1355612-97-3) → zopolrestat (1355612-71-3)

Guidance literature:

With formic acid; water; at 20 ℃; for 22h; Product distribution / selectivity;

Reference yield:

2,3-pyrazinedicarboxylic anhydride (4744-50-7) → zopolrestat (1355612-71-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: chloroform / 48 h / 62 °C

2.1: hydrazine / ethanol / 3 h / 80 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

4.1: water; formic acid / 22 h / 20 °C

With formic acid; potassium tert-butylate; water; hydrazine; In ethanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid (73763-86-7) → zopolrestat (1355612-71-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: hydrazine / methanol / 2 h / 0 - 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

4.1: water; formic acid / 22 h / 20 °C

With formic acid; potassium tert-butylate; water; 1,1'-carbonyldiimidazole; hydrazine; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

5-trifluoromethyl-2-chloromethylbenzothiazole

tert-butyl 2-(8-oxo-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl)acetate

3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid

2,3-pyrazinedicarboxylic anhydride

Refernces