IDH-305

Base Information

Chemical Name:IDH-305
CAS No.:1628805-46-8
Molecular Formula:C₂₃H₂₂F₄N₆O₂
Molecular Weight:490.46
Hs Code.:
Mol file:1628805-46-8.mol

Synonyms:

Suppliers and Price of IDH-305

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2''-(trifluoromethyl)[3,4''-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-2-oxazolidinone
2.5mg
$ 630.00

DC Chemicals
IDH-305 >98%
100 mg
$ 1700.00

ChemScene
IDH-305 98.75%
200mg
$ 3480.00

ChemScene
IDH-305 98.75%
50mg
$ 1440.00

ChemScene
IDH-305 98.75%
100mg
$ 2280.00

ChemScene
IDH-305 98.75%
10mg
$ 576.00

ChemScene
IDH-305 98.75%
5mg
$ 336.00

ChemScene
IDH-305 98.75%
1mg
$ 132.00

Cayman Chemical
IDH305 ≥98%
10mg
$ 587.00

Cayman Chemical
IDH305 ≥98%
1mg
$ 69.00

Total 9 raw suppliers

Chemical Property of IDH-305

Chemical Property:

Boiling Point:597.6±60.0 °C(Predicted)
PKA:4.07±0.10(Predicted)
Density:1.370±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2''-(trifluoromethyl)[3,4''-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (4R)-4-[(1S)-1-Fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2''-(trifluoromethyl)[3,4''-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-2-oxazolidinone, is an inhibitor of isocitrate dehydrogenase (IDH) which is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle.

Technology Process of IDH-305

There total 24 articles about IDH-305 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: (S)-1-(4-methyl-2’-(trifluoromethyl)-[3,4’-bipyridin]-6-yl)ethanamine

: (R)-4-((S)-1-fluoroethyl)-3-(2-fluoropyrimidin-4-yl)-oxazolidin-2-one

: 1628805-46-8
IDH-305

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 110 ℃; for 1h;
DOI:10.1021/acsmedchemlett.7b00342

Reference yield:

: (S)-1-(4-methyl-2’-(trifluoromethyl)-[3,4’-bipyridin]-6-yl)ethanamine

: (R)-4-((R)-1-fluoroethyl)-3-(2-fluoropyrimidin-4-yl)oxazolidin-2-one

: 1628805-46-8
(R)-4-((R)-1-fluoroethyl)-3-(2-(((S)-1-(4-methyl-2'-(trifluoromethyl)-[3,4'-bipyridin]-6-yl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 110 ℃; for 1h;
DOI:10.1021/acsmedchemlett.7b00342

Reference yield:

: (S)-tert-butyl (1-(5-bromo-4-methylpyridin-2-yl)ethyl)carbamate

: 1628805-46-8
IDH-305

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / -78 - 20 °C

2.2: MP-carbonate

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 110 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;