C₂₄H₃₆O₄

Base Information

• Chemical Name: C₂₄H₃₆O₄
• CAS No.: 952496-64-9
• Molecular Formula: C₂₄H₃₆O₄
• Molecular Weight: 388.547
• Mol file: 952496-64-9.mol

Synonyms:

Chemical Property of C₂₄H₃₆O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₃₆O₄

There total 24 articles about C₂₄H₃₆O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H38O4 → C24H36O4 (952496-64-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2007.07.005

Reference yield:

5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentane-1,3-diol (919608-47-2) → C24H36O4 (952496-64-9)

Guidance literature:

Multi-step reaction with 22 steps

1.1: 3.59 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

2.1: 98 percent / TEA / CH₂Cl₂ / 0 - 20 °C

3.1: 84 percent / CSA; methanol / 2 h / 20 °C

4.1: 80 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

5.1: 98 percent / TEA / CH₂Cl₂ / 0 - 20 °C

6.1: 95 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

7.1: 82 percent / PCC; 4 Angstroem molecular sieves / CH₂Cl₂ / 2 h / 20 °C

8.1: TiCl₄ / CH₂Cl₂ / 0.25 h / -78 °C

8.2: 95 percent / CH₂Cl₂ / 0.5 h / -78 °C

9.1: 66 percent / lithium aluminum hydride / diethyl ether / 0 - 20 °C

10.1: 90 percent / sodium hexamethyldisilazide / tetrahydrofuran; dimethylformamide / 0 - 20 °C

11.1: O₃ / CH₂Cl₂ / 0.17 h / -78 °C

11.2: 97 percent / triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

12.1: 97 percent / magnesium bromide etherate / CH₂Cl₂ / 1 h / 20 °C

13.1: O₃ / CH₂Cl₂ / 0.25 h / -78 °C

13.2: triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

14.1: 851 mg / sodium borohydride / methanol / 0 - 20 °C

15.1: 92 percent / TEA / CH₂Cl₂ / 14 h / 0 °C

16.1: 89 percent / PPTS / benzene / 2 h / Heating

17.1: 90 percent / NaI / acetone / 2 h / Heating

18.1: 91 percent / n-Bu₃SnH; Et₃B; air / toluene; hexane / -78 °C

19.1: 100 percent / lithium borohydride / diethyl ether; tetrahydrofuran / 0 - 20 °C

20.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

21.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C

22.1: 68.0 mg / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; lithium borohydride; air; triethyl borane; 4 A molecular sieve; TEA; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; titanium tetrachloride; Dess-Martin periodane; ozone; magnesium bromide ethyl etherate; pyridinium chlorochromate; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; benzene; 4.1: Williamson ether synthesis / 20.1: Dess-Martin oxidation / 22.1: Dess-Martin oxidation;

DOI:10.1016/j.tet.2007.07.005

Reference yield:

methanesulfonic acid 5-(1-methyl-2-oxo-ethyl)-tetrahydro-furan-2-ylmethyl ester (919608-15-4) → C24H36O4 (952496-64-9)

Guidance literature:

Multi-step reaction with 15 steps

1.1: TiCl₄ / CH₂Cl₂ / 0.25 h / -78 °C

1.2: 95 percent / CH₂Cl₂ / 0.5 h / -78 °C

2.1: 66 percent / lithium aluminum hydride / diethyl ether / 0 - 20 °C

3.1: 90 percent / sodium hexamethyldisilazide / tetrahydrofuran; dimethylformamide / 0 - 20 °C

4.1: O₃ / CH₂Cl₂ / 0.17 h / -78 °C

4.2: 97 percent / triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

5.1: 97 percent / magnesium bromide etherate / CH₂Cl₂ / 1 h / 20 °C

6.1: O₃ / CH₂Cl₂ / 0.25 h / -78 °C

6.2: triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

7.1: 851 mg / sodium borohydride / methanol / 0 - 20 °C

8.1: 92 percent / TEA / CH₂Cl₂ / 14 h / 0 °C

9.1: 89 percent / PPTS / benzene / 2 h / Heating

10.1: 90 percent / NaI / acetone / 2 h / Heating

11.1: 91 percent / n-Bu₃SnH; Et₃B; air / toluene; hexane / -78 °C

12.1: 100 percent / lithium borohydride / diethyl ether; tetrahydrofuran / 0 - 20 °C

13.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

14.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C

15.1: 68.0 mg / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; lithium borohydride; air; triethyl borane; TEA; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; titanium tetrachloride; Dess-Martin periodane; ozone; magnesium bromide ethyl etherate; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; benzene; 13.1: Dess-Martin oxidation / 15.1: Dess-Martin oxidation;

DOI:10.1016/j.tet.2007.07.005

upstream raw materials:

methanesulfonic acid 5-(1-methyl-2-oxo-ethyl)-tetrahydro-furan-2-ylmethyl ester

2-(5-methyl-tetrahydro-furan-2-yl)-hex-5-en-3-ol

5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentane-1,3-diol

methanesulfonic acid 5-(2-hydroxy-1-methyl-ethyl)-tetrahydro-furan-2-ylmethyl ester