(R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-fluorophenyl)methanol

Base Information

Chemical Name:(R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-fluorophenyl)methanol
CAS No.:1332487-55-4
Molecular Formula:C₃₂H₄₆FNO₂Si
Molecular Weight:523.807
Hs Code.:

(R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-fluorophenyl)methanol

Synonyms:

Suppliers and Price of (R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-fluorophenyl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-fluorophenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-fluorophenyl)methanol

There total 10 articles about (R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-fluorophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₉FINO₂Si

: 287944-10-9
2-cyclopent-1-enyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1332487-55-4
(R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-fluorophenyl)methanol

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In tetrahydrofuran; at 50 ℃; for 36h; Inert atmosphere;
DOI:10.1021/jm500431d

Reference yield:

: 873-95-0
1-amino-5,5-dimethylcyclohexen-3-one

: 1332487-55-4
(R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-fluorophenyl)methanol

Guidance literature:: Multi-step reaction with 10 steps

1: 0.17 h / 210 °C

2: trichlorophosphate / N,N-dimethyl-formamide / 12 h / 80 °C

3: sodium iodide; acetyl chloride / acetonitrile / 3 h / 50 °C

4: (1R,2S)-1-Amino-2-indanol; borane Ν,Ν-diethylaniline complex / tetrahydrofuran / 28 h / 0 - 20 °C

5: 2,6-dimethylpyridine / tetrahydrofuran / 12 h / 20 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; toluene / 12 h / 85 °C / Inert atmosphere

7: diisobutylaluminium hydride / dichloromethane / 2 h / 0 °C

8: Dess-Martin periodane / dichloromethane / 12 h / 0 - 20 °C

9: isopropylmagnesium chloride / tetrahydrofuran / 12 h / -40 - 20 °C

10: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran / 36 h / 50 °C / Inert atmosphere

With 2,6-dimethylpyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; borane Ν,Ν-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; isopropylmagnesium chloride; diisobutylaluminium hydride; Dess-Martin periodane; acetyl chloride; cesium fluoride; sodium iodide; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 6: |Negishi Coupling / 10: |Suzuki Coupling;
DOI:10.1021/jm500431d

Reference yield:

: 1332486-06-2
ethyl 2,4-dihydroxy-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-3-carboxylate

: 1332487-55-4
(R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-fluorophenyl)methanol

Guidance literature:: Multi-step reaction with 9 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 12 h / 80 °C

2: sodium iodide; acetyl chloride / acetonitrile / 3 h / 50 °C

3: (1R,2S)-1-Amino-2-indanol; borane Ν,Ν-diethylaniline complex / tetrahydrofuran / 28 h / 0 - 20 °C

4: 2,6-dimethylpyridine / tetrahydrofuran / 12 h / 20 °C

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; toluene / 12 h / 85 °C / Inert atmosphere

6: diisobutylaluminium hydride / dichloromethane / 2 h / 0 °C

7: Dess-Martin periodane / dichloromethane / 12 h / 0 - 20 °C

8: isopropylmagnesium chloride / tetrahydrofuran / 12 h / -40 - 20 °C

9: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran / 36 h / 50 °C / Inert atmosphere

With 2,6-dimethylpyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; borane Ν,Ν-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; isopropylmagnesium chloride; diisobutylaluminium hydride; Dess-Martin periodane; acetyl chloride; cesium fluoride; sodium iodide; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 5: |Negishi Coupling / 9: |Suzuki Coupling;
DOI:10.1021/jm500431d