3-(Bromomethyl)-5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazole

Base Information

Chemical Name:3-(Bromomethyl)-5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazole
CAS No.:119540-35-1
Molecular Formula:C17H14BrClN2O
Molecular Weight:377.668
Hs Code.:
DSSTox Substance ID:DTXSID90564863
Wikidata:Q82449714

Synonyms:119540-35-1;SCHEMBL9349968;DTXSID90564863;DJSZJUUVRFWQBW-UHFFFAOYSA-N;3-(Bromomethyl)-5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazole;3-Bromomethyl-5-(4-chlorophenyl)-1-(4-methoxyphenyl) pyrazole

Suppliers and Price of 3-(Bromomethyl)-5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-(Bromomethyl)-5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazole

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:375.99780
Heavy Atom Count:22
Complexity:344

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)N2C(=CC(=N2)CBr)C3=CC=C(C=C3)Cl

Technology Process of 3-(Bromomethyl)-5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazole

There total 4 articles about 3-(Bromomethyl)-5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 119540-33-9
5-(4-Chlorophenyl)-3-hydroxymethyl-1-(4-methoxyphenyl)pyrazole

: 119540-35-1
3-Bromomethyl-5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazole

Guidance literature:: With phosphorus tribromide; In benzene; for 1h; Heating;
DOI:10.1002/jhet.5570270716

Reference yield:

: 119540-31-7
3-Carboethoxy-5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazole

: 119540-35-1
3-Bromomethyl-5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: DIBAL / tetrahydrofuran / -78 - 20 °C

2: CBr₄; PPh₃ / CH₂Cl₂

With carbon tetrabromide; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.09.048

Reference yield:

: 99-91-2
para-chloroacetophenone

: 119540-35-1
3-Bromomethyl-5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiHMDS / diethyl ether

1.2: TsOH / tetrahydrofuran / 40 °C

2.1: DIBAL / tetrahydrofuran / -78 - 20 °C

3.1: CBr₄; PPh₃ / CH₂Cl₂

With carbon tetrabromide; diisobutylaluminium hydride; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2005.09.048