1-phenylprop-2-ynyl acetate

Base Information

• Chemical Name: 1-phenylprop-2-ynyl acetate
• CAS No.: 16169-88-3
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.199
• Mol file: 16169-88-3.mol

Synonyms:

Chemical Property of 1-phenylprop-2-ynyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenylprop-2-ynyl acetate

There total 15 articles about 1-phenylprop-2-ynyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-Phenyl-2-propyn-1-ol (4187-87-5) + acetic anhydride (108-24-7) → 1-phenylprop-2-ynyl acetate (16169-88-3,84681-19-6,116119-86-9,116182-55-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1016/j.tet.2009.06.019

Reference yield: 92.0%

1-Phenyl-2-propyn-1-ol (4187-87-5) + acetic acid (64-19-7,77671-22-8) → 1-phenylprop-2-ynyl acetate (16169-88-3,84681-19-6,116119-86-9,116182-55-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1039/c6cc02563c

Reference yield: 89.0%

1-phenyl-3-(tributylstannyl)prop-2-yn-1-yl acetate → 1-phenylprop-2-ynyl acetate (16169-88-3,84681-19-6,116119-86-9,116182-55-9)

Guidance literature:

With triphenylborane; water; benzaldehyde; In tetrahydrofuran; hexane; at 50 ℃; for 0.5h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03761

upstream raw materials:

1-Phenyl-2-propyn-1-ol

acetic anhydride

acetyl chloride

1-phenyl-3-(trimethylsilyl)prop-2-yn-1-yl acetate

Downstream raw materials:

3-phenyl-1-butyne

1-methoxy-1-phenylpropyne

1-methyl-3-phenylallene

(R)-1-phenyl-2-propyn-1-ol

Refernces

• 1、 Pradhan, Tapas R.,Mohapatra, Debendra K.. "Neighboring Carbonyl Group Assisted Oxyacetoxylation of Propargylic Carboxylates with Retention of Chirality under Metal Free Condition". supporting information. p. 3605 - 3611. Retrieved 2019/07/04.
• 2、 Horino, Yoshikazu,Murakami, Miki,Aimono, Ataru,Lee, Jun Hee,Abe, Hitoshi. "Trialkylborane-Mediated Multicomponent Reaction for the Diastereoselective Synthesis of Anti-δ,δ-Disubstituted Homoallylic Alcohols". supporting information. p. 476 - 480. Retrieved 2019/01/14.