methyl ((S)-1-(2-(2-((3R,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:methyl ((S)-1-(2-(2-((3R,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
CAS No.:1365541-50-9
Molecular Formula:C₄₉H₇₃BrN₄O₆Si₂
Molecular Weight:950.217
Hs Code.:

methyl ((S)-1-(2-(2-((3R,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Chemical Property of methyl ((S)-1-(2-(2-((3R,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Technology Process of methyl ((S)-1-(2-(2-((3R,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

There total 7 articles about methyl ((S)-1-(2-(2-((3R,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872703-59-8
{(1S)-1-[N'-(4-bromobenzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester

: C₃₄H₅₁NO₄Si₂

: 1365541-50-9
methyl ((S)-1-(2-(2-((3R,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: {(1S)-1-[N'-(4-bromobenzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester; C₃₄H₅₁NO₄Si₂; With acetic acid; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm201620t

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 1365541-50-9
methyl ((S)-1-(2-(2-((3R,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 25 °C

2.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 20 °C

3.1: acetic acid / tetrahydrofuran / 0.17 h / 20 °C

3.2: 20 °C

With sodium periodate; osmium(VIII) oxide; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm201620t

Reference yield:

: 7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8
(1S,2R)-1-amino-2-indanol

: 1365541-50-9
methyl ((S)-1-(2-(2-((3R,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: 1-butyl-3-methylimidazolium Tetrafluoroborate / 0.58 h / 180 °C / Microwave irradiation

3.1: triethylamine / dichloromethane / 0 - 25 °C

4.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 20 °C

5.1: acetic acid / tetrahydrofuran / 0.17 h / 20 °C

5.2: 20 °C

With sodium periodate; osmium(VIII) oxide; acetic acid; triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm201620t