(S)-2-{4-[(2-Carbamimidoylsulfanyl-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

Base Information

Chemical Name:(S)-2-{4-[(2-Carbamimidoylsulfanyl-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide
CAS No.:130379-68-9
Molecular Formula:BrH*C₂₉H₃₆N₆O₆S
Molecular Weight:677.619
Hs Code.:

(S)-2-{4-[(2-Carbamimidoylsulfanyl-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

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Chemical Property of (S)-2-{4-[(2-Carbamimidoylsulfanyl-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

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Technology Process of (S)-2-{4-[(2-Carbamimidoylsulfanyl-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

There total 5 articles about (S)-2-{4-[(2-Carbamimidoylsulfanyl-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18731-19-6
3,4-dihydro-2,6-dimethyl-4-oxoquinazoline

: 130379-68-9
(S)-2-{4-[(2-Carbamimidoylsulfanyl-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CHCl₃ / 6 h / 50 °C / Irradiation

2: 38 percent / 2,6-lutidine / dimethylformamide / 18 h / 80 °C

3: N,N-dimethyl-acetamide / 17 h / 100 °C

With 2,6-dimethylpyridine; N-Bromosuccinimide; Perbenzoic acid; In chloroform; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a024

Reference yield:

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 130379-68-9
(S)-2-{4-[(2-Carbamimidoylsulfanyl-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: 12 percent / 2,6-lutidine / dimethylformamide / 17 h / 90 °C

2: 38 percent / 2,6-lutidine / dimethylformamide / 18 h / 80 °C

3: N,N-dimethyl-acetamide / 17 h / 100 °C

With 2,6-dimethylpyridine; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a024

Reference yield:

: 80014-89-7
diethyl N-4-<(2-bromoethyl)amino>benzoyl-L-glutamate

: 130379-68-9
(S)-2-{4-[(2-Carbamimidoylsulfanyl-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / 2,6-lutidine / dimethylformamide / 18 h / 80 °C

2: N,N-dimethyl-acetamide / 17 h / 100 °C

With 2,6-dimethylpyridine; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a024