(2α,7α,8aβ)-4-amino-5-chloro-2-methoxy-N-benzamide

Base Information

Chemical Name:(2α,7α,8aβ)-4-amino-5-chloro-2-methoxy-N-benzamide
CAS No.:115114-03-9
Molecular Formula:C₂₂H₂₅ClFN₃O₂
Molecular Weight:417.911
Hs Code.:

(2α,7α,8aβ)-4-amino-5-chloro-2-methoxy-N-<octahydro-2-(2-fluorophenyl)indolizin-7-yl>benzamide

Synonyms:

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Chemical Property of (2α,7α,8aβ)-4-amino-5-chloro-2-methoxy-N-benzamide

Chemical Property:

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Technology Process of (2α,7α,8aβ)-4-amino-5-chloro-2-methoxy-N-benzamide

There total 8 articles about (2α,7α,8aβ)-4-amino-5-chloro-2-methoxy-N-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-Acetylamino-5-chloro-N-[(2S,7R,8aR)-2-(2-fluoro-phenyl)-octahydro-indolizin-7-yl]-2-methoxy-benzamide

: 115114-03-9
(2α,7α,8aβ)-4-amino-5-chloro-2-methoxy-N-benzamide

Guidance literature:: With sodium hydroxide; In ethanol; for 2h; Heating;
DOI:10.1021/jm00117a008

Reference yield:

: 326-62-5
2-fluorophenyl acetonitrile

: 115114-03-9
(2α,7α,8aβ)-4-amino-5-chloro-2-methoxy-N-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium tert-butoxide / diethyl ether / 48 h / Ambient temperature

2: AlH₃ / tetrahydrofuran / 5 h / Ambient temperature

3: 2.) 2.5 M HCl / 1.) Et₂O, room temperature, 2.) reflux, 2 h

4: 0.01 mol / hydroxylamine hydrochloride, pyridine / ethanol / 1 h / Heating

5: sodium, pentanol / Heating

6: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

7: 2.5 M NaOH / ethanol / 2 h / Heating

With pyridine; aluminium hydride; hydrogenchloride; sodium hydroxide; pentan-1-ol; hydroxylamine hydrochloride; potassium tert-butylate; sodium; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm00117a008

Reference yield:

: 4516-32-9
4-acetylamino-5-chloro-2-methoxy-benzoyl chloride

: 115114-03-9
(2α,7α,8aβ)-4-amino-5-chloro-2-methoxy-N-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 2.5 M NaOH / ethanol / 2 h / Heating

With sodium hydroxide; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00117a008