C₂₂H₁₈F₃N₃O₂

Base Information

Chemical Name:C₂₂H₁₈F₃N₃O₂
CAS No.:1359945-90-6
Molecular Formula:C₂₂H₁₈F₃N₃O₂
Molecular Weight:413.399
Hs Code.:

C<sub>22</sub>H<sub>18</sub>F<sub>3</sub>N<sub>3</sub>O<sub>2</sub>

Synonyms:

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Chemical Property of C₂₂H₁₈F₃N₃O₂

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Technology Process of C₂₂H₁₈F₃N₃O₂

There total 4 articles about C₂₂H₁₈F₃N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: C₁₂H₉F₃N₂O

: 86911-82-2
2,3-dihydro-6-methyl-1H-indole

: 1359945-90-6
C₂₂H₁₈F₃N₃O₂

Guidance literature:: bis(trichloromethyl) carbonate; C₁₂H₉F₃N₂O; In tetrahydrofuran; at 0 ℃; for 0.75h; Inert atmosphere;

2,3-dihydro-6-methyl-1H-indole; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ml300008j

Reference yield:

: 3420-02-8
6-methylindole

: 1359945-90-6
C₂₂H₁₈F₃N₃O₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium cyanoborohydride; acetic acid / 20 °C

2.1: tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

2.2: 0.25 h / 0 °C / Inert atmosphere

2.3: 0 - 20 °C / Inert atmosphere

With sodium cyanoborohydride; acetic acid; In tetrahydrofuran;
DOI:10.1021/ml300008j

Reference yield:

: 914636-35-4
3-bromo-5-(trifluoromethoxy)aniline

: 1359945-90-6
C₂₂H₁₈F₃N₃O₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane / 1 h / 120 °C / 12001.2 Torr / Microwave irradiation

2.1: tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

2.2: 0.25 h / 0 °C / Inert atmosphere

2.3: 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; 1.1: Suzuki coupling;
DOI:10.1021/ml300008j