methyl 6-amino-5-cyano-2-{[(3-cyano-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridin-2-yl)sulfanyl]methyl}-4-(2-fluorophenyl)-4H-pyran-3-carboxylate

Base Information

Chemical Name:methyl 6-amino-5-cyano-2-{[(3-cyano-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridin-2-yl)sulfanyl]methyl}-4-(2-fluorophenyl)-4H-pyran-3-carboxylate
CAS No.:387831-29-0
Molecular Formula:C₂₅H₂₂FN₅O₃S
Molecular Weight:491.546
Hs Code.:
Mol file:387831-29-0.mol

methyl 6-amino-5-cyano-2-{[(3-cyano-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridin-2-yl)sulfanyl]methyl}-4-(2-fluorophenyl)-4H-pyran-3-carboxylate

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Chemical Property of methyl 6-amino-5-cyano-2-{[(3-cyano-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridin-2-yl)sulfanyl]methyl}-4-(2-fluorophenyl)-4H-pyran-3-carboxylate

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Technology Process of methyl 6-amino-5-cyano-2-{[(3-cyano-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridin-2-yl)sulfanyl]methyl}-4-(2-fluorophenyl)-4H-pyran-3-carboxylate

There total 3 articles about methyl 6-amino-5-cyano-2-{[(3-cyano-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridin-2-yl)sulfanyl]methyl}-4-(2-fluorophenyl)-4H-pyran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 290299-52-4
6-methyl-1,2,5,6,7,8-hexahydro-2-thioxo-1,6-naphthyridine-3-carbonitrile

: 6-amino-2-chloromethyl-5-cyano-4-(2-fluoro-phenyl)-4H-pyran-3-carboxylic acid methyl ester

: 387831-29-0
6-amino-5-cyano-2-(3-cyano-6-methyl-5,6,7,8-tetrahydro-[1,6]naphthyridin-2-ylsulfanylmethyl)-4-(2-fluoro-phenyl)-4H-pyran-3-carboxylic acid methyl ester

Guidance literature:: In ethanol; at 40 - 45 ℃;
DOI:10.1023/B:RUCB.0000011877.60574.34

Reference yield:

: 32807-28-6,935731-94-5
Methyl 4-chloroacetoacetate

: 387831-29-0
6-amino-5-cyano-2-(3-cyano-6-methyl-5,6,7,8-tetrahydro-[1,6]naphthyridin-2-ylsulfanylmethyl)-4-(2-fluoro-phenyl)-4H-pyran-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / Et₃N / Heating

2: 59 percent / ethanol / 40 - 45 °C

With triethylamine; In ethanol;
DOI:10.1023/B:RUCB.0000011877.60574.34

Reference yield:

: 446-52-6
2-Fluorobenzaldehyde

: 387831-29-0
6-amino-5-cyano-2-(3-cyano-6-methyl-5,6,7,8-tetrahydro-[1,6]naphthyridin-2-ylsulfanylmethyl)-4-(2-fluoro-phenyl)-4H-pyran-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / Et₃N / Heating

2: 59 percent / ethanol / 40 - 45 °C

With triethylamine; In ethanol;
DOI:10.1023/B:RUCB.0000011877.60574.34