(3-PHENYL-4,5-DIHYDRO-5-ISOXAZOLYL)METHANOL

Base Information

• Chemical Name: (3-PHENYL-4,5-DIHYDRO-5-ISOXAZOLYL)METHANOL
• CAS No.: 119897-89-1
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol file: 119897-89-1.mol

Synonyms:((5R)-3-phenyl-4,5-dihydroisoxazol-5-yl)methan-1-ol;(3-phenyl-4,5-dihydro-5-isoxazolyl)methanol;5-Isoxazolemethanol,4,5-dihydro-3-phenyl-,(R);

Chemical Property of (3-PHENYL-4,5-DIHYDRO-5-ISOXAZOLYL)METHANOL

Chemical Property:

• PSA: 41.82000
• LogP: 0.60750

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-PHENYL-4,5-DIHYDRO-5-ISOXAZOLYL)METHANOL

There total 31 articles about (3-PHENYL-4,5-DIHYDRO-5-ISOXAZOLYL)METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C15H15N3O2 (1142349-87-8) → (R)-3-phenyl-Δ2-isoxazoline-5-methanol (119897-89-1)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1016/j.tetlet.2009.02.178

Reference yield: 85.0%

(2S,3aS,7aS)-1-((R)-3-Phenyl-4,5-dihydro-isoxazole-5-carbonyl)-octahydro-indole-2-carboxylic acid ethyl ester (153391-18-5) → (R)-3-phenyl-Δ2-isoxazoline-5-methanol (119897-89-1) + (2S,3aS,7aS)-(octahydro-indol-2-yl)-methanol

Guidance literature:

With L-Selectride; In tetrahydrofuran; at 25 ℃; for 1h;

DOI:10.1016/S0040-4039(00)61728-8

Reference yield: 66.0%

((R)-3-tert-Butyl-1,1-dioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-((R)-3-phenyl-4,5-dihydro-isoxazol-5-yl)-methanone (137610-10-7) → (R)-3-phenyl-Δ2-isoxazoline-5-methanol (119897-89-1)

Guidance literature:

With L-Selectride; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4039(00)93489-0

upstream raw materials:

3-phenyl-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester

((3aS,6R,7aR)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)((R)-3-phenyl-4,5-dihydroisoxazol-5-yl)methanone

(4R)-2,2-dimethyl-4-phenyl-3-<(5R)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine

((R)-3-tert-Butyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-((R)-3-phenyl-4,5-dihydro-isoxazol-5-yl)-methanone

Downstream raw materials:

4-phenyl-2-oxa-3-aza-bicyclo[3.1.0]hex-3-ene

(2R,4R)-4-phenyl-1,2,4-butanetriol

(R)-5-Methoxymethyl-3-phenyl-4,5-dihydro-isoxazole

(R)-3,4-dihydroxy-1-phenylbutan-1-one