3-[1-(3-Methoxy-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid 3-methoxy-benzyl ester

Base Information

Chemical Name:3-[1-(3-Methoxy-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid 3-methoxy-benzyl ester
CAS No.:147936-96-7
Molecular Formula:C₄₄H₄₄N₂O₅S
Molecular Weight:712.91
Hs Code.:

3-[1-(3-Methoxy-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid 3-methoxy-benzyl ester

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Chemical Property of 3-[1-(3-Methoxy-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid 3-methoxy-benzyl ester

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Technology Process of 3-[1-(3-Methoxy-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid 3-methoxy-benzyl ester

There total 10 articles about 3-[1-(3-Methoxy-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid 3-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146775-28-2
2-chloromethyl-5-phenylpyridine

: 147936-96-7
3-[1-(3-Methoxy-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid 3-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 1 h

2: 97 percent / 1 N LiOH / tetrahydrofuran / 2 h / Heating

3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 16 h

With lithium hydroxide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008

Reference yield:

: 147936-58-1
5-phenyl-2-picoline N-oxide

: 147936-96-7
3-[1-(3-Methoxy-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid 3-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / phosphoryl chloride, Et₃N / CH₂Cl₂

2: NaH / dimethylformamide / 1 h

3: 97 percent / 1 N LiOH / tetrahydrofuran / 2 h / Heating

4: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 16 h

With lithium hydroxide; sodium hydride; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008

Reference yield:

: methyl 5-(t-butylthio)-2,2-dimethyl-4-oxopentanoate

: 147936-96-7
3-[1-(3-Methoxy-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid 3-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 55 percent / 2-methyl-propan-2-ol / 24 h / Heating

2: 62 percent / pyridine hydrochloride / 2 h / 175 °C

3: 1.) NaH / 1.) DMF, 25 deg C, 10 min, 2.) DMF, 16 h

4: 2.) p-toluenesulfonic acid / 1.) 1,2-dichlorobenzene, reflux, 16 h, 2.) 1,2-dichlorobenzene, 150 deg C, 45 min

5: NaH / dimethylformamide / 1 h

6: 97 percent / 1 N LiOH / tetrahydrofuran / 2 h / Heating

7: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 16 h

With lithium hydroxide; pyridine hydrochloride; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00071a008