(+)-tert-butyl (2R)-2-[(1S)-1-({(2S)-2-(benzyloxycarbonyl)amino-2-[(2R)-1-(tert-butoxycarbonyl)piperidin-2-yl]acetyl}amino)-2-methoxy-2-oxoethyl]piperidin-1-ylcarboxylate

Base Information

Chemical Name:(+)-tert-butyl (2R)-2-[(1S)-1-({(2S)-2-(benzyloxycarbonyl)amino-2-[(2R)-1-(tert-butoxycarbonyl)piperidin-2-yl]acetyl}amino)-2-methoxy-2-oxoethyl]piperidin-1-ylcarboxylate
CAS No.:948591-22-8
Molecular Formula:C₃₃H₅₀N₄O₉
Molecular Weight:646.781
Hs Code.:

(+)-tert-butyl (2R)-2-[(1S)-1-({(2S)-2-(benzyloxycarbonyl)amino-2-[(2R)-1-(tert-butoxycarbonyl)piperidin-2-yl]acetyl}amino)-2-methoxy-2-oxoethyl]piperidin-1-ylcarboxylate

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Chemical Property of (+)-tert-butyl (2R)-2-[(1S)-1-({(2S)-2-(benzyloxycarbonyl)amino-2-[(2R)-1-(tert-butoxycarbonyl)piperidin-2-yl]acetyl}amino)-2-methoxy-2-oxoethyl]piperidin-1-ylcarboxylate

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Technology Process of (+)-tert-butyl (2R)-2-[(1S)-1-({(2S)-2-(benzyloxycarbonyl)amino-2-[(2R)-1-(tert-butoxycarbonyl)piperidin-2-yl]acetyl}amino)-2-methoxy-2-oxoethyl]piperidin-1-ylcarboxylate

There total 4 articles about (+)-tert-butyl (2R)-2-[(1S)-1-({(2S)-2-(benzyloxycarbonyl)amino-2-[(2R)-1-(tert-butoxycarbonyl)piperidin-2-yl]acetyl}amino)-2-methoxy-2-oxoethyl]piperidin-1-ylcarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 948591-22-8
(+)-tert-butyl (2R)-2-[(1S)-1-({(2S)-2-(benzyloxycarbonyl)amino-2-[(2R)-1-(tert-butoxycarbonyl)piperidin-2-yl]acetyl}amino)-2-methoxy-2-oxoethyl]piperidin-1-ylcarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / triethylamine / tetrahydrofuran; dioxane; H₂O / 15 h / 0 - 20 °C

2: LiOH / H₂O; tetrahydrofuran / 15 h / 0 - 20 °C

3: 347 mg / BOP; ethyldiisopropylamine / CH₂Cl₂ / 0 - 20 °C

With lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.tet.2007.05.062

Reference yield:

: 675125-03-8
(-)-methyl (2S)-[2-benzyloxycarbonylamino-2-piperidin-(2'R)-yl]acetate

: 948591-22-8
(+)-tert-butyl (2R)-2-[(1S)-1-({(2S)-2-(benzyloxycarbonyl)amino-2-[(2R)-1-(tert-butoxycarbonyl)piperidin-2-yl]acetyl}amino)-2-methoxy-2-oxoethyl]piperidin-1-ylcarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / triethylamine / tetrahydrofuran; dioxane; H₂O / 15 h / 0 - 20 °C

2: LiOH / H₂O; tetrahydrofuran / 15 h / 0 - 20 °C

3: 347 mg / BOP; ethyldiisopropylamine / CH₂Cl₂ / 0 - 20 °C

With lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.tet.2007.05.062

Reference yield:

: 948591-19-3
(+)-methyl (2S)-[2-(benzyloxycarbonylamino)-2-((2'R)-(N-tert-butoxycarbonyl)piperidin-2'-yl)]acetate

: 948591-22-8
(+)-tert-butyl (2R)-2-[(1S)-1-({(2S)-2-(benzyloxycarbonyl)amino-2-[(2R)-1-(tert-butoxycarbonyl)piperidin-2-yl]acetyl}amino)-2-methoxy-2-oxoethyl]piperidin-1-ylcarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: LiOH / H₂O; tetrahydrofuran / 15 h / 0 - 20 °C

2: 347 mg / BOP; ethyldiisopropylamine / CH₂Cl₂ / 0 - 20 °C

With lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2007.05.062