Methyl 2--3-(3,4,5-tribenzyloxyphenyl)-propenoate

Base Information

• Chemical Name: Methyl 2--3-(3,4,5-tribenzyloxyphenyl)-propenoate
• CAS No.: 89525-33-7
• Molecular Formula: C₄₂H₄₈N₂O₈
• Molecular Weight: 708.852
• Mol file: 89525-33-7.mol

Synonyms:

Chemical Property of Methyl 2--3-(3,4,5-tribenzyloxyphenyl)-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 2--3-(3,4,5-tribenzyloxyphenyl)-propenoate

There total 2 articles about Methyl 2--3-(3,4,5-tribenzyloxyphenyl)-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → Methyl 2--3-(3,4,5-tribenzyloxyphenyl)-propenoate (89525-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 5 h / Ambient temperature

2: 1.) lithium diisopropylamide / 1.) THF, hexane, 2.) 2 h, room temp.

With dicyclohexyl-carbodiimide; lithium diisopropyl amide; In dichloromethane;

DOI:10.1055/s-1984-30730

Reference yield:

3,4,5-tribenzyloxybenzaldehyde (6137-86-6) + Methyl 2-[(S)-2-tert-butoxycarbonylamino-4-methylpentanoylamino]-2-(dimethoxyphosphoryl)acetate (89525-02-0) → Methyl 2--3-(3,4,5-tribenzyloxyphenyl)-propenoate (89525-33-7) + Methyl 2--3-(3,4,5-tribenzyloxyphenyl)-propenoate (89525-34-8)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, hexane, 2.) 2 h, room temp.;

DOI:10.1055/s-1984-30730

upstream raw materials:

3,4,5-tribenzyloxybenzaldehyde

Methyl 2-[(S)-2-tert-butoxycarbonylamino-4-methylpentanoylamino]-2-(dimethoxyphosphoryl)acetate

N-tert-butoxycarbonyl-L-leucine