5-(2-Fluorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

Base Information

Chemical Name:5-(2-Fluorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol
CAS No.:81450-57-9
Molecular Formula:C₁₆H₁₃FN₂O
Molecular Weight:268.29
Hs Code.:
DSSTox Substance ID:DTXSID00512693
NSC Number:742549

Synonyms:81450-57-9;DTXSID00512693;NSC742549;NSC-742549;3H-Imidazo[2, 5-(2-fluorophenyl)-2,5-dihydro-;5-(2-Fluorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

Suppliers and Price of 5-(2-Fluorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-Fluorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:268.10119120
Heavy Atom Count:20
Complexity:427

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN2C(=N1)C3=CC=CC=C3C2(C4=CC=CC=C4F)O

Technology Process of 5-(2-Fluorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

There total 1 articles about 5-(2-Fluorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 936-49-2
2-phenyl-2-imidazoline

: 394-35-4
methyl 2-fluorobenzoate

: 81450-57-9
5-(2-Fluoro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.)THF/hexane, 50 deg C, 3 h 2.)r.t., overnight;
DOI:10.1002/jhet.5570180812

Reference yield: 84.0%

: 81450-57-9
5-(2-Fluoro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

: 73268-33-4
5-(2'-fluorophenyl)-5H-imidazo[2,1-a]isoindole

Guidance literature:: In acetic acid; for 8h; Heating;
DOI:10.1002/jhet.5570180812

Reference yield:

: 81450-57-9
5-(2-Fluoro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

: 57960-37-9
9H-dibenzimidazo<1,2-a>azepin-9-one

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / acetic acid / 8 h / Heating

2: 76 percent / NaH/dry air / dimethylformamide / 48 h / Ambient temperature

With air; sodium hydride; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570180812