(E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester

Base Information

• Chemical Name: (E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester
• CAS No.: 312709-29-8
• Molecular Formula: C₃₆H₅₃NO₅Si
• Molecular Weight: 607.906

Synonyms:

Chemical Property of (E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester

There total 10 articles about (E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-oxocyclopent)acetic acid (104115-44-8,1460-38-4) → (E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester (312709-29-8)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 95 percent / toluene / Heating

2.1: 99 percent / TiCl₄ / CH₂Cl₂ / -78 - 20 °C

3.1: 92 percent / Na; NH₃ / tetrahydrofuran; ethanol / -78 °C

4.1: 96 percent / DMAP / tetrahydrofuran

5.1: LiHMDS / tetrahydrofuran / -40 °C

5.2: 90 percent / tetrahydrofuran / -78 - 0 °C

6.1: 89 percent / LiOH / tetrahydrofuran; H₂O

7.1: Et₃N / tetrahydrofuran

8.1: NaBH₄ / methanol

9.1: 95 percent / Et₃N; DMAP / CH₂Cl₂

10.1: 9-BBN / tetrahydrofuran

10.2: Pd(dppf)Cl₂; AsPh₃; Cs₂CO₃ / dimethylformamide; H₂O

With dmap; lithium hydroxide; sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; ammonia; sodium; titanium tetrachloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; 1.1: Cycloaddition / 2.1: allylation / 3.1: debenzylation / 4.1: Acylation / 5.1: Metallation / 5.2: Methylation / 6.1: Hydrolysis / 7.1: Acylation / 8.1: Reduction / 9.1: silylation / 10.1: hydroboration / 10.2: alkyl Suzuki-coupling;

DOI:10.1016/S0040-4039(99)01170-3

Reference yield:

(3R,5aR,8aS)-3-phenyl-hexahydro-1-oxa-3a-aza-cyclopenta[c]pentalen-4-one (161779-70-0) → (E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester (312709-29-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 99 percent / TiCl₄ / CH₂Cl₂ / -78 - 20 °C

2.1: 92 percent / Na; NH₃ / tetrahydrofuran; ethanol / -78 °C

3.1: 96 percent / DMAP / tetrahydrofuran

4.1: LiHMDS / tetrahydrofuran / -40 °C

4.2: 90 percent / tetrahydrofuran / -78 - 0 °C

5.1: 89 percent / LiOH / tetrahydrofuran; H₂O

6.1: Et₃N / tetrahydrofuran

7.1: NaBH₄ / methanol

8.1: 95 percent / Et₃N; DMAP / CH₂Cl₂

9.1: 9-BBN / tetrahydrofuran

9.2: Pd(dppf)Cl₂; AsPh₃; Cs₂CO₃ / dimethylformamide; H₂O

With dmap; lithium hydroxide; sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; ammonia; sodium; titanium tetrachloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1.1: allylation / 2.1: debenzylation / 3.1: Acylation / 4.1: Metallation / 4.2: Methylation / 5.1: Hydrolysis / 6.1: Acylation / 7.1: Reduction / 8.1: silylation / 9.1: hydroboration / 9.2: alkyl Suzuki-coupling;

DOI:10.1016/S0040-4039(99)01170-3

Reference yield:

(3aR,6aS)-6a-Allyl-hexahydro-cyclopenta[b]pyrrol-2-one (250595-64-3) → (E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester (312709-29-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 96 percent / DMAP / tetrahydrofuran

2.1: LiHMDS / tetrahydrofuran / -40 °C

2.2: 90 percent / tetrahydrofuran / -78 - 0 °C

3.1: 89 percent / LiOH / tetrahydrofuran; H₂O

4.1: Et₃N / tetrahydrofuran

5.1: NaBH₄ / methanol

6.1: 95 percent / Et₃N; DMAP / CH₂Cl₂

7.1: 9-BBN / tetrahydrofuran

7.2: Pd(dppf)Cl₂; AsPh₃; Cs₂CO₃ / dimethylformamide; H₂O

With dmap; lithium hydroxide; sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: Acylation / 2.1: Metallation / 2.2: Methylation / 3.1: Hydrolysis / 4.1: Acylation / 5.1: Reduction / 6.1: silylation / 7.1: hydroboration / 7.2: alkyl Suzuki-coupling;

DOI:10.1016/S0040-4039(99)01170-3

upstream raw materials:

(E)-methyl 3-iodoacrylate

{1-allyl-2-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-carbamic acid tert-butyl ester

(2-oxocyclopent)acetic acid

(3R,5aR,8aS)-3-phenyl-hexahydro-1-oxa-3a-aza-cyclopenta[c]pentalen-4-one

Downstream raw materials:

{(1R,5S,7R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-aza-spiro[4.5]dec-7-yl}-acetic acid methyl ester

C₃₇H₅₃NO₃Si

4-{(1R,5S,7R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-aza-spiro[4.5]dec-7-yl}-3-oxo-butyric acid tert-butyl ester

C₃₇H₅₃NO₄Si

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 312709-29-8 (E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send