Technology Process of 2-(2-trifluoroacetamidophenyl)adamantan-2-ol
There total 4 articles about 2-(2-trifluoroacetamidophenyl)adamantan-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium cyanide;
for 2h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) sodium hydride; 2.) n-butyl-lithium, hexamethylphosphoric triamide / 1.) THF, room temperature, 0.5 h, hexane, -78 deg C, 30 min; 2.) THF, -78 deg C, 1 h
2: 53 percent / aq. potassium hydroxide / 1.5 h / Heating
3: 27 percent / potassium cyanide / 2 h / Ambient temperature
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium cyanide; potassium hydroxide; n-butyllithium; sodium hydride;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) sodium hydride; 2.) n-butyl-lithium, hexamethylphosphoric triamide / 1.) THF, room temperature, 0.5 h, hexane, -78 deg C, 30 min; 2.) THF, -78 deg C, 1 h
2: 53 percent / aq. potassium hydroxide / 1.5 h / Heating
3: 27 percent / potassium cyanide / 2 h / Ambient temperature
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium cyanide; potassium hydroxide; n-butyllithium; sodium hydride;