(2S)-benzyl-6-(hydroxymethyl)-2,3-dihydro-4H-benzopyran

Base Information

Chemical Name:(2S)-benzyl-6-(hydroxymethyl)-2,3-dihydro-4H-benzopyran
CAS No.:109210-10-8
Molecular Formula:C₁₇H₁₈O₂
Molecular Weight:254.329
Hs Code.:

Synonyms:

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Chemical Property of (2S)-benzyl-6-(hydroxymethyl)-2,3-dihydro-4H-benzopyran

Chemical Property:

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Technology Process of (2S)-benzyl-6-(hydroxymethyl)-2,3-dihydro-4H-benzopyran

There total 12 articles about (2S)-benzyl-6-(hydroxymethyl)-2,3-dihydro-4H-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142617-75-2
(2S)-benzyl-6-(methoxycarbonyl)-2,3-dihydro-4H-benzopyran

: 109210-10-8
(2S)-benzyl-6-(hydroxymethyl)-2,3-dihydro-4H-benzopyran

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 20 ℃; for 1h;
DOI:10.1002/jhet.5570290223

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 109210-10-8
(2S)-benzyl-6-(hydroxymethyl)-2,3-dihydro-4H-benzopyran

Guidance literature:: Multi-step reaction with 12 steps

1: 50 percent / sodium nitrite, 1 M H₂SO₄ / H₂O / Ambient temperature

2: 94 percent / 98percent H₂SO₄ / CH₂Cl₂ / 18 h / Heating

3: 70 percent / (C₆H₅)3P, diisopropyl azodicarboxylate / tetrahydrofuran / Ambient temperature

4: 98 percent / NaBH₄ / tetrahydrofuran; H₂O / 30 h / Ambient temperature

5: 90 percent / triphenylphosphine dibromide / CH₂Cl₂ / 28 °C

6: methanesulfonic acid / 20 °C

7: Et₃N, Ac₂O / dimethylformamide / 1 h / 37 °C

8: 4 N HCl / acetone / Ambient temperature

9: sodium hypochlorite / CH₂Cl₂ / 4 h / 30 °C

10: 252 g / 6 N HCl / methanol / 2 h / 50 °C

11: 70 percent / H₂, HCl / 10percent Pd/C / tetrahydrofuran; H₂O / 30 h / 2585.7 Torr

12: sodium bis-(2-methoxyethoxy)aluminium hydride / toluene / 1 h / 20 °C

With hydrogenchloride; sodium hypochlorite; sodium tetrahydroborate; methanesulfonic acid; di-isopropyl azodicarboxylate; sulfuric acid; hydrogen; acetic anhydride; triethylamine; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium nitrite; dibromotriphenylphosphorane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1002/jhet.5570290223

Reference yield:

: 20312-36-1
L-3-phenyllactic acid

: 109210-10-8
(2S)-benzyl-6-(hydroxymethyl)-2,3-dihydro-4H-benzopyran

Guidance literature:: Multi-step reaction with 11 steps

1: 94 percent / 98percent H₂SO₄ / CH₂Cl₂ / 18 h / Heating

2: 70 percent / (C₆H₅)3P, diisopropyl azodicarboxylate / tetrahydrofuran / Ambient temperature

3: 98 percent / NaBH₄ / tetrahydrofuran; H₂O / 30 h / Ambient temperature

4: 90 percent / triphenylphosphine dibromide / CH₂Cl₂ / 28 °C

5: methanesulfonic acid / 20 °C

6: Et₃N, Ac₂O / dimethylformamide / 1 h / 37 °C

7: 4 N HCl / acetone / Ambient temperature

8: sodium hypochlorite / CH₂Cl₂ / 4 h / 30 °C

9: 252 g / 6 N HCl / methanol / 2 h / 50 °C

10: 70 percent / H₂, HCl / 10percent Pd/C / tetrahydrofuran; H₂O / 30 h / 2585.7 Torr

11: sodium bis-(2-methoxyethoxy)aluminium hydride / toluene / 1 h / 20 °C

With hydrogenchloride; sodium hypochlorite; sodium tetrahydroborate; methanesulfonic acid; di-isopropyl azodicarboxylate; sulfuric acid; hydrogen; acetic anhydride; triethylamine; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; dibromotriphenylphosphorane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1002/jhet.5570290223