trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol

Base Information

Chemical Name:trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol
CAS No.:81218-97-5
Molecular Formula:C₂₀H₂₀N₂O₄S
Molecular Weight:384.456
Hs Code.:

trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benz<cd>indol-5-ol

Synonyms:

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Chemical Property of trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol

Chemical Property:

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Technology Process of trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol

There total 2 articles about trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81206-38-4
4-azido-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one

: 81218-97-5
trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / tetrahydrofuran / 2 h / Ambient temperature

2: NaBH₄ / tetrahydrofuran; ethanol / 1 h / Ambient temperature

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jo00132a040

Reference yield:

: 81206-39-5
4-(acetylamino)-5-acetoxy-1,3-dihydro-1-(p-tolylsulfonyl)benzindole

: 81218-97-5
trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; for 1h; Ambient temperature;
DOI:10.1021/jo00132a040

Reference yield:

: 81218-97-5
trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol

: 81244-90-8
(-)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.5 h

2: 100 percent / KOH / ethanol / 0.17 h / 50 - 55 °C

With dmap; potassium hydroxide; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;
DOI:10.1021/jo00132a040