(4R)-1-{[1-(6-chloropyridin-3-yl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide

Base Information

Chemical Name:(4R)-1-{[1-(6-chloropyridin-3-yl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide
CAS No.:1268445-09-5
Molecular Formula:C₂₆H₂₃Cl₂F₃N₄O₅S
Molecular Weight:631.46
Hs Code.:

(4R)-1-{[1-(6-chloropyridin-3-yl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide

Synonyms:

Suppliers and Price of (4R)-1-{[1-(6-chloropyridin-3-yl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R)-1-{[1-(6-chloropyridin-3-yl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R)-1-{[1-(6-chloropyridin-3-yl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide

There total 5 articles about (4R)-1-{[1-(6-chloropyridin-3-yl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1252634-04-0
(4R)-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide

: C₉H₇Cl₂NO

: 1268445-09-5
(4R)-1-{[1-(6-chloropyridin-3-yl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 22 ℃; for 3.5h; Inert atmosphere;
DOI:10.1002/anie.201006781

Reference yield:

: 854267-90-6
1-(6-chloropyridin-3-yl)cyclopropanecarboxylic acid

: 1268445-09-5
(4R)-1-{[1-(6-chloropyridin-3-yl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 17 h / 22 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 22 °C / Inert atmosphere

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/anie.201006781

Reference yield:

: 1252634-02-8
tert-butyl (2S,4R)-4-([2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl)-2-([(1-cyanocyclopropyl)amino]carbonyl)pyrrolidine-1-carboxylate

: 1268445-09-5
(4R)-1-{[1-(6-chloropyridin-3-yl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: formic acid / 6.5 h / 22 °C

1.2: 0 °C / pH 9

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 22 °C / Inert atmosphere

With formic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/anie.201006781