(R,E)-2,2,2-trifluoro-N-hexyl-N-(1-phenylhex-4-en-3-yl)acetamide

Base Information

• Chemical Name: (R,E)-2,2,2-trifluoro-N-hexyl-N-(1-phenylhex-4-en-3-yl)acetamide
• CAS No.: 1246566-67-5
• Molecular Formula: C₂₀H₂₈F₃NO
• Molecular Weight: 355.444
• Mol file: 1246566-67-5.mol

Synonyms:

Chemical Property of (R,E)-2,2,2-trifluoro-N-hexyl-N-(1-phenylhex-4-en-3-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,E)-2,2,2-trifluoro-N-hexyl-N-(1-phenylhex-4-en-3-yl)acetamide

There total 9 articles about (R,E)-2,2,2-trifluoro-N-hexyl-N-(1-phenylhex-4-en-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S,E)-6-phenylhex-3-en-2-yl 2,2,2-trifluoro-N-hexylacetimidate → (R,E)-2,2,2-trifluoro-N-hexyl-N-(1-phenylhex-4-en-3-yl)acetamide (1246566-67-5)

Guidance literature:

With C₁₂₄H₉₄Cl₂Fe₂N₄O₄Pd₂S₂; silver trifluoroacetate; In dichloromethane; at 20 ℃; for 72h; optical yield given as %ee; Inert atmosphere;

DOI:10.1002/asia.201000386

Reference yield:

(E)-6-phenylhex-3-en-2-yl 2,2,2-trifluoro-N-hexylacetimidate → (R,E)-2,2,2-trifluoro-N-hexyl-N-(1-phenylhex-4-en-3-yl)acetamide (1246566-67-5)

Guidance literature:

With C₉₂H₇₆Cl₂Fe₂N₂O₂Pd₂; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; silver nitrate; In dichloromethane; at 40 ℃; for 2h; optical yield given as %ee; Inert atmosphere; Darkness;

DOI:10.1002/asia.201000386

Reference yield:

((5S)-5-((tert-butyldimethylsilyl)oxy)-4-hydroxy-1-phenylhexan-3-yl)diphenylphosphine oxide → (R,E)-2,2,2-trifluoro-N-hexyl-N-(1-phenylhex-4-en-3-yl)acetamide (1246566-67-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

2.2: Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: C₁₂₄H₉₄Cl₂Fe₂N₄O₄Pd₂S₂; silver trifluoroacetate / dichloromethane / 72 h / 20 °C / Inert atmosphere

With C₁₂₄H₉₄Cl₂Fe₂N₄O₄Pd₂S₂; tetrabutyl ammonium fluoride; silver trifluoroacetate; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/asia.201000386

upstream raw materials:

ClC(CF₃)N(n-C₆H₁₃)

(S)-(3E)-6-phenylhex-3-en-2-ol

(E)-6-phenyl-3-hexen-2-one

(E)-6-phenyl-2-hydroxy-hex-3-ene