Technology Process of N,N'-[(tert-butoxycarbonyl)methyl]-N,N'-[((6-methoxycarbonyl)pyridin-2-yl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane
There total 2 articles about N,N'-[(tert-butoxycarbonyl)methyl]-N,N'-[((6-methoxycarbonyl)pyridin-2-yl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium carbonate / N,N-dimethyl-formamide / 24 h / 50 °C / Molecular sieve
2: potassium carbonate; thiophenol / tetrahydrofuran / 72 h / 20 °C
3: sodium carbonate / acetonitrile / 24 h / Heating
With
sodium carbonate; potassium carbonate; thiophenol;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja4049493
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydrogencarbonate / tetrahydrofuran / 50 °C / Cooling with ice
2: sodium carbonate / N,N-dimethyl-formamide / 24 h / 50 °C / Molecular sieve
3: potassium carbonate; thiophenol / tetrahydrofuran / 72 h / 20 °C
4: sodium carbonate / acetonitrile / 24 h / Heating
With
sodium hydrogencarbonate; sodium carbonate; potassium carbonate; thiophenol;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja4049493
- Guidance literature:
-
With
hydrogenchloride; palladium on carbon; hydrogen; acetic acid;
In
water;
at 20 ℃;
for 1h;
DOI:10.1021/ja4049493
